Related Products of 20198-19-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Reactions of some quinazoline compounds with ethoxymethylenemalonic acid derivatives. Author is Deady, Leslie W.; Mackay, Maureen F.; Werden, Dianne M..
The reactions of Et (1,4-dihydro-4-oxoquinazolin-2-yl)acetate (I, R = CH2CO2Et) and 2-aminoquinazolin-4(1H)-one (I, R = NH2) with ethoxymethylenemalonate derivatives EtOHC:CR1R2 [R1 = R2 = CO2Et (II); R1 = CN, R2 = CN, CO2Et (III)] are reported, and different results are obtained to those previously found with quinoline analogs. Reaction of I (R = CH2CO2Et) with II gives a pyrido[1,2-a]quinazoline, while with III, 2-(pyridin-2-yl)aminobenzoates IV (R2 = CN, R3 = Et, CH2CH2CH; R2 = CO2Et, R3 = Et) are formed, presumably by ring-opening of intermediate pyrido[2,1-b]quinazolines. Reaction of I (R = NH2) with II likewise results in ultimate cyclization onto N-1 of the quinazoline, while reactions with III give isolable pyrimido[2,1-b]quinazolines. These are readily cleaved under mild conditions. The structure of IV (R2 = CN, R3 = Et) was proved by x-ray crystallog.
After consulting a lot of data, we found that this compound(20198-19-0)Related Products of 20198-19-0 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis