Fernandes, Daniel J.; Cardenas, Rafael M.; Bertino, Joseph R.; Hynes, John B. published an article about the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2 ).Formula: C8H7N3O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:20198-19-0) through the article.
A series of title compounds (I; Z = NHCH2, CH2NH, CH2NMe, CH2S, CH2O, (CH2)2, CHONCH2) were evaluated as inhibitors of colon adenocarcinoma and the folate-dependent enzymes, thymidylate synthase [9031-61-2] and dihydrofolate reductase [9002-03-3]. Of the drugs tested, IAHQ (I; Z = NHCH2) [56239-21-5], when administered at 85 mg/kg on days 2 and 10 after tumor implantation, delayed the growth of colon tumor Number 38, and resulted in 6 of 20 tumor-free animals at 90 days. In contrast, methotrexate had no effect on the growth of colon tumor Number 38 at maximally tolerated doses. IAHQ was also active against human colon adenocarcinoma cells (HCT-8) in tissue culture, requiring a concentration of 5 × 10-7 M to inhibit cell growth by 50% after 72 h continuous exposure.
This literature about this compound(20198-19-0)Formula: C8H7N3Ohas given us a lot of inspiration, and I hope that the research on this compound(2-Aminoquinazolin-4(3H)-one) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis