Chemistry is traditionally divided into organic and inorganic chemistry. category: chiral-nitrogen-ligands, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 108-47-4
Retention of ionizable compounds in high-performance liquid chromatography 14. Acid-base pK values in acetonitrile-water mobile phases
Linear relationships between sspKa values in acetonitrile-water mixtures and wwpKa values in pure water have been established for five families of compounds: aliphatic carboxylic acids, aromatic carboxylic acids, phenols, amines, and pyridines. The parameters (slope and intercept) of the linear correlations have been related with acetonitrile-water composition. The proposed equations allow accurate estimation of the pKa values of any member of the studied families at any acetonitrile-water composition up to 60% of acetonitrile in volume (100% for pyridines). Conversely, the same equations can be used to estimate aqueous pKa values from chromatographic pKa values obtained from any acetonitrile-water mobile phase between the composition range studied. Estimation of pKa values have been tested with chromatographic literature data.
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Reference£º
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis