In an article, author is Nappi, Manuel, once mentioned the application of 96-47-9, Recommanded Product: 96-47-9, Name is 2-Methyltetrahydrofuran, molecular formula is C5H10O, molecular weight is 86.1323, MDL number is MFCD00005367, category is chiral-nitrogen-ligands. Now introduce a scientific discovery about this category.
Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp(3))-H Amination to Azetidines
A palladium(II)-catalyzed -C-H amination of cyclic alkyl amines to deliver highly substituted azetidines is reported. The use of a benziodoxole tosylate oxidant in combination with AgOAc was found to be crucial for controlling a selective reductive elimination pathway to the azetidines. The process is tolerant of a range of functional groups, including structural features derived from chiral -amino alcohols, and leads to the diastereoselective formation of enantiopure azetidines.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis