Research on new synthetic routes about 6684-39-5

As far as I know, this compound(6684-39-5)Computed Properties of C5H3Cl2NO2S can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Pan, Ting; Ding, Yanchao; Wu, Liyang; Liang, Liting; He, Xin; Li, Qianwen; Bai, Chuan; Zhang, Hui researched the compound: 2-Chloro-5-pyridinesulfonyl chloride( cas:6684-39-5 ).Computed Properties of C5H3Cl2NO2S.They published the article 《Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors》 about this compound( cas:6684-39-5 ) in European Journal of Medicinal Chemistry. Keywords: antiviral HBV capsid protein inhibitor aminothiazole preparation structure activity. We’ll tell you more about this compound (cas:6684-39-5).

The capsid assembly is an essential step for Hepatitis B Virus (HBV) life cycle and is an important target for anti-HBV drug development. In this report, we identified a hit compound with aminothiazole structure by the high throughput screening (HTS) which inhibited the interaction of HBV capsid protein within the cells. The structure hopping and SAR studies of the hit compound afforded compound 79 with potent anti-HBV replication activity and good basic drug-like properties. The working mechanism studies showed that compound 79 could bind to the similar binding site of known HBV capsid inhibitor with heteroaryldihydropyrimidine (HAP) scaffold, through similar hydrophobic interactions but with a different hydrogen bond. This compound exerted potent inhibitory effect upon HBV production, either in cell culture or in mice with no obvious acute toxicity. We propose that further development of this compound could lead to novel potent anti-HBV inhibitors that target HBV capsid assembly.

As far as I know, this compound(6684-39-5)Computed Properties of C5H3Cl2NO2S can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis