When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. Quality Control of 2,4-Dimethylpyridine
The reaction of pyridine and methylpyridines with alpha, beta-unsaturated carboxylic acids, such as: acrylic, methacrylic, crotonic, cinnamic, itaconic, fumaric and maleic acid, as well as the reactions of di- and trimethylpyridines with acrylic and maleic acids were studied. The reactions developed by such compounds may be, actually, considered as a competition between addition and neutralization, resulting betaine and/or salt. The factors influencing the development reaction are the chemical structure of the amine, acid and solvent, as well as the reaction duration. The order of reactivity for the same reactions was established by half-times. The 1H-NMR methodology was applied for elucidating both the chemically obtained structures and the half-times.
I am very proud of our efforts over the past few months and hope to 108-47-4 help many people in the next few years.
Reference：
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis