Application In Synthesis of Tri(naphthalen-1-yl)phosphine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Enantioselective synthesis of β2-amino acids using rhodium-catalyzed hydrogenation. Author is Hoen, Rob; Tiemersma-Wegman, Theodora; Procuranti, Barbara; Lefort, Laurent; de Vries, Johannes G.; Minnaard, Adriaan J.; Feringa, Ben L..
A series of protected β2-dehydroamino acids has been prepared in three steps from com. available starting materials in good yields. These were used as substrates in rhodium-catalyzed asym. hydrogenation using a mixed ligand system of monodentate phosphoramidites and phosphines. Optimization of the catalyst structure was achieved by high throughput experimentation. High enantioselectivities were obtained (up to 91%) with full conversion for a number of β-amino acids.
There is still a lot of research devoted to this compound(SMILES：C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2)Application In Synthesis of Tri(naphthalen-1-yl)phosphine, and with the development of science, more effects of this compound(3411-48-1) can be discovered.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis