So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yun, L. M.; Babadzhanova, S. B.; Kadyrov, Ch. Sh.; Shakhidoyatov, Kh. M. researched the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0 ).Application In Synthesis of 2-Aminoquinazolin-4(3H)-one.They published the article 《Amidomethylation of quinazoline derivatives by N-methylolphthalimide and -pyrolidinone》 about this compound( cas:20198-19-0 ) in Doklady Akademii Nauk UzSSR. Keywords: quinazolinone amidomethylation; alkylation quinazolinone. We’ll tell you more about this compound (cas:20198-19-0).
Alkylation of 2-amino-4-quinazolinone (I) or its 3-Me derivative with N-(hydroxymethyl)pyrrolidone or -phthalimide took place as expected to give the N-amidomethyl derivatives II and III (R = H, Me). III (R = H) on reaction with N2H4 gave I, HCHO, and NH3. With 4-quinazolinone the alkylation failed; only products of further reaction were isolated.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis