The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Synthesis of potential fungicides in the quinazoline series, the main research direction is quinazoline derivative preparation fungicide; pyrimidoquinazoline preparation fungicide; polymethylenequinazoline fungicide; formylation polymethylenequinazoline; bromination polymethylenequinazoline; chlorosulfonation polymethylenequinazoline.Reference of 2-Aminoquinazolin-4(3H)-one.
Acylaminoquinazolines I (R = MeO, Me, Me2CHCH2, Ph, benzyl, PhCH:CH, p-O2NC6H4, p-MeOC6H4, p-tolyl, 3,5-xylyl) were obtained in 20-69% yield by acylation of the resp. amine. Pyrimidoquinazolines II (R1-3 = H; R1-2 = H, R3 = Me; R1 = Me, R2-3 = H; R1-2 = Me, Ph, R3 = H) were obtained in 61-90% yield by cycloaddition of R1CR2:CR3CO2H with the amine. Polymethylenedihydroquinazolones III (n = 1, 2, 3) were brominated, chlorosulfonated, nitrated and formylated to give 6.1-100% expected products. Aminomethylene derivative IV (X = e.g., NO2; n = 1, 2, 3; NR4R5 = piperidino, morpholino; R4 = R5 = H, Me; R4 = H, R5 = OH, Bu, Me2CHCH2, CMe3) were also prepared Condensation of III (n = 1) with 26 aldehydes and ketones gave V e.g., R6 = Ph, R7 = H). The prepared compounds had low fungicidal activity (no data).
Different reactions of this compound(2-Aminoquinazolin-4(3H)-one)Reference of 2-Aminoquinazolin-4(3H)-one require different conditions, so the reaction conditions are very important.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis