Let¡¯s face it, organic chemistry can seem difficult to learn, Recommanded Product: 1-Chloroethyl carbonochloridate, Especially from a beginner¡¯s point of view. Like 50893-53-3, Name is 1-Chloroethyl carbonochloridate, molecular formula is C13H25NO, belongs to amides-buliding-blocks compound. In a document, author is Wang, Qiang, introducing its new discovery.
Enantioselective Construction of Tertiary Fluoride Stereocenters by Organocatalytic Fluorocyclization
1,1-Disubstituted styrenes with internal oxygen and nitrogen nucleophiles undergo oxidative fluorocyclization reactions with in situ generated chiral iodine(III)-catalysts. The resulting fluorinated tetrahydrofurans and pyrrolidines contain a tertiary carbon-fluorine stereocenter. Application of a new 1-naphthyllactic acid-based iodine(III)-catalyst allows the control of tertiary carbon-fluorine stereocenters with up to 96% ee. Density functional theory calculations are performed to investigate the details of the mechanism and the factors governing the stereoselectivity of the reaction.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis