In an article, author is Han, Yixin, once mentioned the application of 136030-00-7, Name is (1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol, molecular formula is C9H11NO, molecular weight is 149.1897, MDL number is MFCD00216656, category is chiral-nitrogen-ligands. Now introduce a scientific discovery about this category, Application In Synthesis of (1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol.
Method for the Direct Enantioselective Synthesis of Chiral Primary alpha-Amino Ketones by Catalytic alpha-Amination
A useful catalytic enantioselective approach has been developed for the synthesis of chiral ketamine analogs using Rh(II)-catalyzed amination of triisopropylsilyl enol ethers to form alpha-amino ketones with O-(4-nitrophenyl)hydroxylamine as nitrogen donor in 81-91% ee.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis