With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119139-23-0,3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.
EXAMPLE 10 1.4 ml of acetaldehyde dimethyl acetal and 10 mg of p-toluenesulphonic acid were added to a solution of 250 mg of 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione in 40 ml of chloroform. The resulting mixture was heated to reflux for 18 hours under nitrogen. The obtained solution was evaporated and the residue was purified on silica gel with ethyl acetate/petroleum ether (1:2). Recrystallization from chloroform/hexane gave 165 mg of 3,4-bis[1-(1-methoxyethyl)-3-indolyl]-1H-pyrrole-2,5-dione, m.p. 222-224 C.
As the paragraph descriping shows that 119139-23-0 is playing an increasingly important role.
Reference£º
Patent; Hoffmann-La Roche Inc.; US5057614; (1991); A;,
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis