Electric Literature of C8H7N3O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Combined distance geometry analysis of dihydrofolate reductase inhibition by quinazolines and triazines.
QSAR anal. of triazines I (R = H, Br, F, I, Me, MeO, CF3, PhCH2O, etc.) and quinazolines II R = H, OH, SH, H2N, AcNH, Me, etc.; n = 1-3) as inhibitors of rat liver dihydrofolate reductase [9002-03-3] using distance geometry anal. is described. The model was applied to predict the biol. activity of 91 compounds The predicted values showed a root mean square deviation of 0.907 and a correlation coefficient of 0.790. The distance geometry model for the dihydrofolate reductase inhibition is unique in its ability to fit 3 different sets of mols. (3′- and 4′-substituted phenyltriazines and quinazolines) in the same model, and successfully predicts the biol. activity of the compounds
As far as I know, this compound(20198-19-0)Electric Literature of C8H7N3O can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis