Tag: M.W=100-200

Recommanded Product: 14389-12-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Crystal structure of tetraaquabis(4-(5-tetrazolato)pyridyl-N)copper(II) tetrahydrate, Cu(H2O)4(C6H4N5)2·4H2O. Author is Wang, Ji-Wu; Guo, Jin-Xin; Fu, Feng; Li, Dong-Sheng; Wang, Ji-Jiang; Zhang, Mei-Li.

Crystallog. data and at. coordinates are given. The copper atom is coordinated in a distorted octahedral manner and trans-connected to two 4-PTZ anions [d(Cu-N) = 2.034(4) Å] and four mols. of water [d(Cu-O1) = 1.947(4), d(Cu-02) = 2.482(4) Å]. The remaining four water mols. act as lattice water mols. Within the equatorial plane, the sum of the bond angles around the Cu atom is 360 °. The apical O2-Cu-O2′ bond angle is 180 °. In the supramol. complex, the eight water mols. and the noncoordinating N atoms of the tetrazolato ligands form an extensive H-bonding system. All the water form strong H bonds between themselves or with the noncoordinating N atoms of the tetrazolato ligands occur strong H bonds. So, a two-dimensional network structure is constructed by hydrogen bonding interactions. Moreover, a three-dimensional network structure is formed by the face-to-face π-π interactions of the pyridine ring and the tetrazolate ring ligands belonging to adjacent dimeric units with distances of about 3.45 Å.

Different reactions of this compound(5-(4-Pyridyl)-1H-tetrazole)Recommanded Product: 14389-12-9 require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Aminoquinazolin-4(3H)-one(SMILESS: O=C1NC(N)=NC2=C1C=CC=C2,cas:20198-19-0) is researched.Recommanded Product: 1,5-Dibromopentane. The article 《Quantitative analysis of the behavior of Dictyostelium discoideum amoebae: Stringency of pteridine reception》 in relation to this compound, is published in Cell Motility and the Cytoskeleton. Let’s take a look at the latest research on this compound (cas:20198-19-0).

A convenient, sensitive, quant. assay for the measurement of chemotaxis of populations of D. discoideum vegetative amoebae is presented. A strategy for determining the boundary of the bulk of a population of migrating amoebae was devised and is described. This assay employs a dynamic gradient and is independent of deaminase activity. Measurements of chemoattractant capabilities of various pteridines, folates, and mixtures of folate fragments are reported. 2-Amino 4-quinazolinone, a pterin analog without the pyrazine ring nitrogens, is chemotactic. Lumazine, deaminated pterin, inhibits chemotaxis towards pterin but not towards folic acid. Deaminofolic acid is a chemoattractant as are mixtures of lumazine plus aminobenzoylglutamic acid or deaminopteroic acid plus various amino acids. Sep., the components of these mixtures exhibit no ability to stimulate chemotaxis. These mixtures are of fragments that together comprise most of the folate structure. Our results are in accord with sep. receptors for pterin vs. folic acid and with a high stringency for pterin reception but a relative tolerance for folate reception. The possibility of using such mixtures to investigate the requirements of various parts of the folate structure for competent signalling is discussed.

Different reactions of this compound(2-Aminoquinazolin-4(3H)-one)COA of Formula: C8H7N3O require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors, published in 2016, which mentions a compound: 20198-19-0, mainly applied to nitrogen heterocycle Mycobacterium tuberculosis dihydrofolate reductase inhibitor; cyanouracil xanthine quinazolinone heterocycle synthesis tuberculosis; DHFR; FBDD; Mycobacterium tuberculosis; Nitrogen heterocycles, Reference of 2-Aminoquinazolin-4(3H)-one.

Fragment-based drug design was used to identify Mycobacterium tuberculosis (Mtb) dihydrofolate reductase (DHFR) inhibitors. Screening of ligands against the Mtb DHFR enzyme resulted in the identification of multiple fragment hits with IC50 values in the range of 38-90 μM vs. Mtb DHFR and min. inhibitory concentration (MIC) values in the range of 31.5-125 μg/mL. These fragment scaffolds would be useful for anti-tubercular drug design. cyanouracil,xanthines, and quinazolinones.

Different reactions of this compound(2-Aminoquinazolin-4(3H)-one)Reference of 2-Aminoquinazolin-4(3H)-one require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Nazhimov, K. O.; Masharipov, S.; Kasymova, S. S.; Askarav, M. A. published an article about the compound: 2-Aminoquinazolin-4(3H)-one( cas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2 ).Application In Synthesis of 2-Aminoquinazolin-4(3H)-one. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:20198-19-0) through the article.

In order to prepare PVC with high thermooxidative stability, vinyl chloride (I) was copolymerized with unsaturated derivatives of 2-amino-4-quinazolone (UDAQ); photochem. and thermooxidative stabilities of the copolymers were studied. Kinetics of radial suspension polymerization of I with UDAQ was studied; activation energies, reactivity ratios and copolymer compositions were determined; the reaction order with respect to the monomer and initiator was 0.41-0.65. The highest thermooxidative stability was exhibited by I-2-amino-4-quinazolone copolymer (II) prepared in the presence of diisopropylperoxy dicarbonate; thermal degradation of II starts at a temperature 30 K higher than the degradation temperature of PVC. The copolymer films exhibit higher photochem. stability than PVC films. The degree of dehydrochlorination of the copolymers is lower by a factor of 2-3 than that of PVC.

The article 《Synthesis and properties of vinyl chloride copolymers with unsaturated 2-amino-4-quinazolone derivatives》 also mentions many details about this compound(20198-19-0)Application In Synthesis of 2-Aminoquinazolin-4(3H)-one, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of 5-(4-Pyridyl)-1H-tetrazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about 5-(Pyridinium-4-yl)-1H-1,2,3,4-tetrazol-1-ide. Author is Xu, Qian; Xu, Jie.

In the title zwitterionic mol., C6H5N5, the tetrazole and pyridine rings are nearly coplanar, making a dihedral angle of 2.08(1)°. In the crystal, mols. are connected by classical N-H…N and weak C-H…N H bonds. Crystallog. data and at. coordinates are given.

The article 《5-(Pyridinium-4-yl)-1H-1,2,3,4-tetrazol-1-ide》 also mentions many details about this compound(14389-12-9)Safety of 5-(4-Pyridyl)-1H-tetrazole, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14389-12-9, is researched, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5Journal, Article, Acta Crystallographica, Section E: Structure Reports Online called Triaquadichlorido[5-(4-pyridinio)tetrazolato-κN2]cobalt(II) monohydrate, Author is Wang, Bo, the main research direction is crystal structure cobalt pyridinio tetrazolato chloro aqua complex monohydrate; mol structure cobalt pyridiniotetrazolato chloro aqua complex hydrate; hydrogen bond cobalt pyridiniotetrazolato chloro aqua complex monohydrate; pi stacking cobalt pyridiniotetrazolato chloro aqua complex monohydrate; tetrazolato pyridinio cobalt chloro aqua monohydrate crystal mol structure.SDS of cas: 14389-12-9.

Triaquadichloro[5-(4-pyridinio)tetrazolato-κN2]cobalt monohydrate, [CoCl2(C6H5N5)(H2O)3]·H2O, was synthesized by hydrothermal reaction of CoCl2 with 4-(2H-tetrazol-5-yl)pyridine. The CoII cation is coordinated by 2 Cl- ions, 1 N atom from the 5-(4-pyridinio)tetrazolate zwitterion and 3 O atoms from 3 H2O mols. in a distorted octahedral geometry. In the crystal, mols. are linked into a 3-dimensional network by N-H···Cl H bonds and O-H···O/N/Cl H bonds involving both coordinated and uncoordinated H2O mols. Strong π-π stacking is present between parallel pyridinium and tetrazolate rings [centroid-centroid distances = 3.411(2) and 3.436(2) Å]. Crystallog. data are given.

The article 《Triaquadichlorido[5-(4-pyridinio)tetrazolato-κN2]cobalt(II) monohydrate》 also mentions many details about this compound(14389-12-9)SDS of cas: 14389-12-9, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Synthesis of potential fungicides in the quinazoline series, the main research direction is quinazoline derivative preparation fungicide; pyrimidoquinazoline preparation fungicide; polymethylenequinazoline fungicide; formylation polymethylenequinazoline; bromination polymethylenequinazoline; chlorosulfonation polymethylenequinazoline.Reference of 2-Aminoquinazolin-4(3H)-one.

Acylaminoquinazolines I (R = MeO, Me, Me2CHCH2, Ph, benzyl, PhCH:CH, p-O2NC6H4, p-MeOC6H4, p-tolyl, 3,5-xylyl) were obtained in 20-69% yield by acylation of the resp. amine. Pyrimidoquinazolines II (R1-3 = H; R1-2 = H, R3 = Me; R1 = Me, R2-3 = H; R1-2 = Me, Ph, R3 = H) were obtained in 61-90% yield by cycloaddition of R1CR2:CR3CO2H with the amine. Polymethylenedihydroquinazolones III (n = 1, 2, 3) were brominated, chlorosulfonated, nitrated and formylated to give 6.1-100% expected products. Aminomethylene derivative IV (X = e.g., NO2; n = 1, 2, 3; NR4R5 = piperidino, morpholino; R4 = R5 = H, Me; R4 = H, R5 = OH, Bu, Me2CHCH2, CMe3) were also prepared Condensation of III (n = 1) with 26 aldehydes and ketones gave V e.g., R6 = Ph, R7 = H). The prepared compounds had low fungicidal activity (no data).

Different reactions of this compound(2-Aminoquinazolin-4(3H)-one)Reference of 2-Aminoquinazolin-4(3H)-one require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 20198-19-0, is researched, SMILESS is O=C1NC(N)=NC2=C1C=CC=C2, Molecular C8H7N3OJournal, Article, Bioorganic & Medicinal Chemistry Letters called Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists, Author is Pieters, Serge; McGowan, David; Herschke, Florence; Pauwels, Frederik; Stoops, Bart; Last, Stefaan; Embrechts, Werner; Scholliers, Annick; Mostmans, Wendy; Van Dijck, Kris; Van Schoubroeck, Bertrand; Thone, Tine; De Pooter, Dorien; Fanning, Gregory; Rosauro, Mari Luz; Khamlichi, Mourad Daoubi; Houpis, Ioannis; Arnoult, Eric; Jonckers, Tim H. M.; Raboisson, Pierre, the main research direction is diaminoquinazoline preparation toll like receptor 7 agonistic activity; HBV; Quinazoline; TLR7.Reference of 2-Aminoquinazolin-4(3H)-one.

The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure-activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the potent agonist I. Pharmacokinetic and pharmacodynamic studies highlighted I as an orally available endogenous interferon (IFN-α) inducer in mice.

Different reactions of this compound(2-Aminoquinazolin-4(3H)-one)Reference of 2-Aminoquinazolin-4(3H)-one require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ) is researched.Safety of 5-(4-Pyridyl)-1H-tetrazole.Pellizzeri, Steven; Delaney, Sean P.; Korter, Timothy M.; Zubieta, Jon published the article 《Using Terahertz Spectroscopy and Solid-State Density Functional Theory to Characterize a New Polymorph of 5-(4-pyridyl)tetrazole》 about this compound( cas:14389-12-9 ) in Journal of Physical Chemistry A. Keywords: terahertz spectroscopy solid DFT crystallog characterize polymorph pyridyltetrazole. Let’s learn more about this compound (cas:14389-12-9).

A new high-temperature polymorph of 5-(4-pyridyl)tetrazole was discovered and characterized using x-ray crystallog. and terahertz (THz) spectroscopy. The THz spectrum of the new polymorph was compared to the previously published form and was replicated by solid-state d. functional theory. Terahertz spectroscopy was used to determine the influence of the different packing motifs on the mol. and low energy lattice vibrations displayed at 10-100 cm-1. There is only a ∼ 2 cm-1 difference in the primary peak location, caused by a whole mol. rotation along the principal a axis, between the two polymorphic forms. The energy of formation was determined, and the previously known polymorphic form is more stable by ∼0.25 kJ/mol, compared to the newly discovered form.

Different reactions of this compound(5-(4-Pyridyl)-1H-tetrazole)Safety of 5-(4-Pyridyl)-1H-tetrazole require different conditions, so the reaction conditions are very important.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Product Details of 14389-12-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Hydrothermal Preparation of Novel Cd(II) Coordination Polymers Employing 5-(4-Pyridyl)tetrazolate as a Bridging Ligand. Author is Xue, Xiang; Wang, Xi-Sen; Wang, Li-Zhong; Xiong, Ren-Gen; Abrahams, Brendan F.; You, Xiao-Zeng; Xue, Zi-Ling; Che, Chi-Ming.

The reaction of 4-cyanopyridine with NaN3 in the presence of H2O and a Lewis acid (CdCl2) affords a novel 3-dimensional pillared-layered fluorescent and phosphorescent coordination polymer Cd3(OH)2Cl2(4-PTZ)2 (4-PTZ = 5-(4-pyridyl)tetrazolate) (1) while the direct reaction of CdCl2 with H-PTZ gives the simpler species Cd(4-PTZ)2(H2O)2. The solid-state structure and nature of 1 provide an indication of the type of materials that may be formed as intermediates in the Sharpless-Demko reaction for the generation of 5-substituted 1H-tetrazoles.

The article 《Hydrothermal Preparation of Novel Cd(II) Coordination Polymers Employing 5-(4-Pyridyl)tetrazolate as a Bridging Ligand》 also mentions many details about this compound(14389-12-9)Product Details of 14389-12-9, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis