Tag: M.W=100-200

Wang, Fei; Zhang, Jian; Yu, Rongmin; Chen, Shu-Mei; Wu, Xiao-Yuan; Chen, Shan-Ci; Xie, Yi-Ming; Zhou, Wei-Wei; Lu, Can-Zhong published the article 《Topological derivation from centrosymmetry to noncentrosymmetry in a three-dimensional polar framework material》. Keywords: copper bromo pyridyltetrazole polymeric complex preparation SHG.They researched the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ).SDS of cas: 14389-12-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:14389-12-9) here.

Strong second harmonic generation (SHG) response was presented by a three-dimensional polar framework material [Cu2(L)Br]n (1; HL = 5-(4-pyridyl)tetrazole), which was obtained by reacting CuBr with HL under solvothermal conditions and displayed an noncentrosym. (3,4)-connected topol. derived from the centrosym. CdSO4 net.

The article 《Topological derivation from centrosymmetry to noncentrosymmetry in a three-dimensional polar framework material》 also mentions many details about this compound(14389-12-9)SDS of cas: 14389-12-9, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Category: chiral-nitrogen-ligands. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Expanded perlite: an inexpensive natural efficient heterogeneous catalyst for the green and highly accelerated solvent-free synthesis of 5-substituted-1H-tetrazoles using [bmim]N3 and nitriles. Author is Jahanshahi, Roya; Akhlaghinia, Batool.

A versatile, green and highly accelerated protocol for preparing 5-substituted-1H-tetrazoles was reported. In this method, 5-substituted-1H-tetrazoles were synthesized from nitriles and [bmim]N3, in the presence of the expanded perlite as an inexpensive natural efficient heterogeneous catalyst, under solvent-free condition. A wide variety of aryl nitriles underwent [3+2] cycloaddition to afford the desired tetrazoles in good to excellent yields, rapidly. This method had the advantages of high yields, short reaction times, simple methodol. and easy work-up. The catalyst was recovered by simple filtration and reused delivering good yields.

The article 《Expanded perlite: an inexpensive natural efficient heterogeneous catalyst for the green and highly accelerated solvent-free synthesis of 5-substituted-1H-tetrazoles using [bmim]N3 and nitriles》 also mentions many details about this compound(14389-12-9)Category: chiral-nitrogen-ligands, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Product Details of 14389-12-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-(4-Pyridyl)-1H-tetrazole, is researched, Molecular C6H5N5, CAS is 14389-12-9, about Zinc chloride-catalyzed synthesis of 5-substituted 1H-tetrazoles under solvent free condition. Author is Rostamizadeh, Shahnaz; Ghaieni, Hamid; Aryan, Reza; Amani, Ali.

Zinc chloride is an efficient and safe catalyst in the [3 + 2] cycloaddition reaction of organic nitriles with sodium azide in solventless condition. The corresponding 5-substituted 1H tetrazoles were obtained under mild conditions. This method can overcome disadvantages such as: the use of toxic metals and expensive reagents, drastic reaction conditions, water sensitivity and the presence of dangerous hydrazoic acid.

The article 《Zinc chloride-catalyzed synthesis of 5-substituted 1H-tetrazoles under solvent free condition》 also mentions many details about this compound(14389-12-9)Product Details of 14389-12-9, you can pay attention to it, because details determine success or failure

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application In Synthesis of 2-Aminoquinazolin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Identification of the main nitrogen-containing compounds in Ctenopharyngodon idellus by HPLC-Q-TOF-MS. Author is Zhang, You-sheng; Huang, Jia-si; Liu, Xue-ming; Cheng, Jing-rong; Chen, Zhi-yi; Zhang, Ye-hui.

The main nitrogenous compounds in methanol extracts of Ctenopharyngodon idellus were analyzed and identified using high-performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). Both pos. and neg. ionization modes were used to confirm the related chem. compounds and their characteristic fragment ions according to the accurate mol. mass information of the excimer ion peaks and the fragment ions. Using the ChemSpider database, 33 nitrogenous compounds in Ctenopharyngodon idellus were ultimately determined, and the data for the main fragments of each component were analyzed. These 33 nitrogenous compounds included 11 amino acids (eight types of α-amino acids), 12 amines, eight amide compounds, and two heterocyclic nitrogenous compounds The results showed that the structures of monomer compounds in fresh aquatic products and raw materials could be elucidated directly using the HPLC-Q-TOF-MS technique and fragmentation anal. by mass spectrometry, which can improve the efficiency of anal. and identification of chem. components in fresh raw material. This study shows that these techniques are conducive for the identification and anal. of active components and newly generated compounds during the storage of fresh raw materials.

After consulting a lot of data, we found that this compound(20198-19-0)Application In Synthesis of 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Electronic spectra of N-heteroaromatic systems. I. The n-π transitions of monocyclic azines》. Authors are Mason, S. F..The article about the compound:2-Aminoquinazolin-4(3H)-onecas:20198-19-0,SMILESS:O=C1NC(N)=NC2=C1C=CC=C2).Synthetic Route of C8H7N3O. Through the article, more information about this compound (cas:20198-19-0) is conveyed.

The positions and the intensities of the band in the visible and the ultraviolet spectra of monocyclic azines owing to the promotion of an electron from a lone-pair N orbital to a π-orbital of the ring have been measured in the vapor phase and in solution in cyclohexane (I) and H2O. The frequency of the band is determined primarily by the energy of the benzene-like lowest unoccupied π orbital of the azine and by groundstate interaction between lone-pair orbitals on different N atoms. The intensities of the n → π bands of the azines increase with the “”s”” character of the lone-pair N orbitals, but the frequencies of the bands are not greatly affected, owing to orbital-following in the transition. The frequencies (ν) in vapor, νmaximum in I, νmaximum in H2O, all oscillator strength (f) in I, and pKα are given for pyridine, pyrimidine, pyrazine, pyridazine, sym-triazine, 3,5,6-trimethyl-1,2,4-triazine, m-tetrazine.

After consulting a lot of data, we found that this compound(20198-19-0)Synthetic Route of C8H7N3O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Recommanded Product: 20198-19-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Hot Spot Analysis for Driving the Development of Hits into Leads in Fragment-Based Drug Discovery. Author is Hall, David R.; Ngan, Chi Ho; Zerbe, Brandon S.; Kozakov, Dima; Vajda, Sandor.

Fragment-based drug design (FBDD) starts with finding fragment-sized compounds that are highly ligand efficient and can serve as a core moiety for developing high-affinity leads. Although the core-bound structure of a protein facilitates the construction of leads, effective design is far from straightforward. We show that protein mapping, a computational method developed to find binding hot spots and implemented as the FTMap server, provides information that complements the fragment screening results and can drive the evolution of core fragments into larger leads with a minimal loss or, in some cases, even a gain in ligand efficiency. The method places small mol. probes, the size of organic solvents, on a dense grid around the protein and identifies the hot spots as consensus clusters formed by clusters of several probes. The hot spots are ranked based on the number of probe clusters, which predicts the binding propensity of the subsites and hence their importance for drug design. Accordingly, with a single exception the main hot spot identified by FTMap binds the core compound found by fragment screening. The most useful information is provided by the neighboring secondary hot spots, indicating the regions where the core can be extended to increase its affinity. To quantify this information, we calculate the d. of probes from mapping, which describes the binding propensity at each point, and show that the change in the correlation between a ligand position and the probe d. upon extending or repositioning the core moiety predicts the expected change in ligand efficiency.

After consulting a lot of data, we found that this compound(20198-19-0)Recommanded Product: 20198-19-0 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water, published in 2009-11-30, which mentions a compound: 20198-19-0, Name is 2-Aminoquinazolin-4(3H)-one, Molecular C8H7N3O, Name: 2-Aminoquinazolin-4(3H)-one.

A green, rapid, and efficient method was developed for synthesizing quinazolinone derivatives, e.g., I from substituted 2-halobenzoic acids and amidines via microwave-assisted iron-catalyzed cyclization with or without ligand in water or DMF. With these methods, moderate to high yields of the desired products can be obtained from even inactive substrates, such as guanidines. This is the first report on the synthesis of N-heterocyclic compounds by iron-catalyzed C-N coupling in aqueous media.

After consulting a lot of data, we found that this compound(20198-19-0)Name: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 14389-12-9, is researched, SMILESS is C1(C2=NN=NN2)=CC=NC=C1, Molecular C6H5N5Journal, Article, Research Support, Non-U.S. Gov’t, Dalton Transactions called Constructing novel Cd(II) metal-organic frameworks based on different highly connected secondary building units via alteration of reaction conditions, Author is Liu, Yan-Qing; Ren, Guo-Jian; Zhang, Ying-Hui; Xu, Jian; Bu, Xian-He, the main research direction is cadmium pyridyltetrazolate MOF preparation crystal structure photoluminescence; thermal decomposition gas adsorption cadmium pyridyltetrazolate MOF.Related Products of 14389-12-9.

Upon solvothermal reactions between Cd(II) salt and 5-pyridyl-tetrazolate (4-Ptz) under different reaction conditions, three new Cd(II) metal-organic frameworks (MOFs), namely [Cd3(4-Ptz)5(H2O)2(μ3-OH)·3DMA·5H2O·CH3OH]n (1), [Cd5(4-Ptz)8(CH3OH)2(μ3-OH)2·2DMA·4H2O·3CH3OH]n (2) and [{Cd9(4-Ptz)14(AC)2(μ3-OH)2(H2O)4}·8DMA·H2O·3CH3OH]n (3), were synthesized based on different highly connected secondary building units (SBUs). In the presence of triethylamine, 1 was constructed based on an 8-connected triangular trinuclear Cd3 SBU and exhibits a three-dimensional framework, while 2 was generated upon the addition of HCl, assembled through a close packing of the octahedron cages consisting of unprecedented 12-connected 4-Ptz bridged Cd5 SBUs and thus showing high thermal and chem. stability. For generating 3, two different kinds of Cd3 SBUs, including an 8-connected triangular SBU and a 10-connected linear SBU, were constructed and further integrated into a distorted octahedron-based net under the addition of both triethylamine and NaCl. In addition to the structural anal., the authors also focused on the investigation of gas adsorption and solid-state fluorescence properties of 2.

After consulting a lot of data, we found that this compound(14389-12-9)Related Products of 14389-12-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines.Formula: C8H7N3O.

A continuous-flow process for the in situ on-demand generation of cyanogen bromide (BrCN) from bromine and potassium cyanide that makes use of membrane-separation technol. is described. In order to circumvent the handling, storage, and transportation of elemental bromine, a continuous bromine generator using bromate-bromide syn-proportionation can optionally be attached upstream. Monitoring and quantification of BrCN generation was enabled through the implementation of in-line FTIR technol. With the Br2 and BrCN generators connected in series, 0.2 mmol BrCN per min was produced, which corresponds to a 0.8 M solution of BrCN in dichloromethane. The modular Br2/BrCN generator was employed for the synthesis of a diverse set of biol. relevant five- and six-membered cyclic amidines and guanidines. The set-up can either be operated in a fully integrated continuous format or, where reactive crystallization is beneficial, in semi-batch mode.

After consulting a lot of data, we found that this compound(20198-19-0)Formula: C8H7N3O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Recommanded Product: 2-Aminoquinazolin-4(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Aminoquinazolin-4(3H)-one, is researched, Molecular C8H7N3O, CAS is 20198-19-0, about Exploring the Limits of DNA Size: Naphtho-Homologated DNA Bases and Pairs. Author is Lee, Alex H. F.; Kool, Eric T..

A new design for DNA bases and base pairs is described in which the pyrimidine bases are widened by naphtho-homologation. Two naphtho-homologated deoxyribosides, dyyT (1) and dyyC (2), were synthesized and could be incorporated into oligonucleotides as suitably protected phosphoramidite derivatives The deoxyribosides were found to be fluorescent, with emission maxima at 446 and 433 nm, resp. Studies with single substitutions of 1 and 2 in the natural DNA context revealed exceptionally strong base stacking propensity for both. Sequences containing multiple substitutions of 1 and 2 paired opposite adenine and guanine were subsequently mixed and studied by several anal. methods. Data from UV mixing experiments, FRET measurements, fluorescence quenching experiments, and hybridizations on beads suggest that complementary “”double-wide DNA”” (yyDNA) strands may self-assemble into helical complexes with 1:1 stoichiometry. Data from thermal denaturation plots and CD spectra were less conclusive. Control experiments in one sequence context gave evidence that yyDNA helixes, if formed, are preferentially antiparallel and are sequence. Hypothesized base pairing schemes are analogous to Watson-Crick pairing, but with glycosidic C1′-C1′ distances widened by over 45%, to ca. 15.2 Å. The possible self-assembly of the double-wide DNA helix establishes a new limit for the size of information-encoding, DNA-like mols., and the fluorescence of yyDNA bases suggests uses as reporters in monomeric and oligomeric forms.

After consulting a lot of data, we found that this compound(20198-19-0)Recommanded Product: 2-Aminoquinazolin-4(3H)-one can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis