Tag: M.W:200-300

Wen, Xiaojin; Li, Xinyao; Luo, Xiao; Wang, Weijin; Song, Song; Jiao, Ning published an article about the compound: 1,5-Dibromopentane( cas:111-24-0,SMILESS:BrCCCCCBr ).Product Details of 111-24-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:111-24-0) through the article.

The intramol. Csp3-H and/or C-C bond amination was very important in modern organic synthesis due to its efficiency in the construction of diversified N-heterocycles. A novel intramol. cyclization of alkyl azides for the synthesis of cyclic imines I [Ar = Ph, 4-MeC6H4, 4-OMeC6H4, etc.; R = H, 2-Me, 2-Et, etc.] and tertiary amines II [n = 1, 2] through selective Csp3-H and/or C-C bond cleavage was reported. Two C-N single bonds or a C=N double bond were efficiently constructed in these transformations. The carbocation mechanism differed from the reported metal nitrene intermediates and therefore enabled metal-free and new transformation.

The article 《Intramolecular Csp3-H/C-C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines》 also mentions many details about this compound(111-24-0)Product Details of 111-24-0, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 6-Chloro-N-(pyridin-4-ylmethyl)pyridine-3-sulfonamide, published in 2013-12-31, which mentions a compound: 6684-39-5, mainly applied to crystal structure chloropyridinylmethylpyridinesulfonamide; mol structure chloropyridinylmethylpyridinesulfonamide; hydrogen bond chloropyridinylmethylpyridinesulfonamide, COA of Formula: C5H3Cl2NO2S.

In 6-chloro-N-(pyridin-4-ylmethyl)pyridine-3-sulfonamide, C11H10ClN3O2S, the dihedral angle between the pyridine rings is 46.85(12)°. The N atom of the chloropyridine ring is anti to the N-H bond. In the crystal, mols. are linked through N-H···N H bonds into zigzag chains parallel to [001] with a C(7) graph-set motif. Crystallog. data are given.

After consulting a lot of data, we found that this compound(6684-39-5)COA of Formula: C5H3Cl2NO2S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.McFadden, T. M. C.; Platakyte, R.; Stocka, J.; Ceponkus, J.; Aleksa, V.; Carrigan-Broda, T.; Sablinskas, V.; Rodziewicz, P.; Guirgis, G. A. researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).HPLC of Formula: 111-24-0.They published the article 《Experimental (Raman and IR) and computational (DFT, MP2) studies of conformational diversity of 1-chloromethyl-1-fluorosilacyclohexane》 about this compound( cas:111-24-0 ) in Journal of Molecular Structure. Keywords: chloromethyl fluorosilacyclohexane conformation. We’ll tell you more about this compound (cas:111-24-0).

Since 1-chloromethyl-1-fluorosilacyclohexane is a newly synthesized mol. compound its structural parameters and conformational stability is unknown. Raman and IR vibrational spectroscopy methods were employed for anal. of this mol. IR spectra were recorded for both gas phase and liquid sample, whereas the Raman experiments were performed in the liquid state. Addnl., low temperature matrix isolation IR spectra were recorded after isolating the mol. in argon and nitrogen matrixes. For the assignment of the exptl. spectral bands, theor. DFT/B3LYP/aug-cc-pVDZ and MP2/aug-cc-pVDZ calculations were performed. From the calculations it was found that 1-chloromethyl-1-fluorosilacyclohexane may exist in twelve different conformational forms out of which the chair axial trans conformer is the most stable form. However, there are three more chair type conformers – equatorial trans, equatorial gauche and axial gauche that are stable enough to be observed in the exptl. spectra.

After consulting a lot of data, we found that this compound(111-24-0)HPLC of Formula: 111-24-0 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Arakawa, Yuki; Komatsu, Kenta; Ishida, Yuko; Tsuji, Hideto published the article 《Thioether-linked azobenzene-based liquid crystal dimers exhibiting the twist-bend nematic phase over a wide temperature range》. Keywords: thioether azobenzene liquid crystal dimer preparation; twist bend nematic phase.They researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Name: 1,5-Dibromopentane. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:111-24-0) here.

Two homologous series of sulfur-containing thioether-linked 4-cyanoazobenzene-based liquid crystal (LC) dimers were developed: a sym. series based on 4-cyanoazobenzene arms [(CN)AzoSnSAzo(CN)] and a non-sym. series based on 4-cyanoazobenzene and 4-cyanobiphenyl arms [(CN)AzoSnSCB]. They contained different flexible oligomethylene spacers (CnH2n) consisting of odd numbers of carbon atoms (n = 3, 5, 7, 9, and 11). The sym. (CN)AzoSnSAzo(CN) dimers with n = 5, 7, 9, and 11 showed an elusive monotropic twist-bend nematic (NTB) phase, while all the non-sym. (CN)AzoSnSCB dimers exhibited the NTB phase. Notably, the NTB phase observed for non-sym. (CN)AzoS7SCB could be supercooled to room temperature, leading to a glassy NTB phase. (CN)AzoS9SCB showed a similar tendency accompanied by partial crystallization These are the first reported examples of azobenzene-based LC dimers exhibiting a broad temperature range of NTB phases supercooled to room temperature Such prominent stability of the NTB phase is due to the supercooling effect assisted by the synergy of mol. bend arising from thioether linkages and non-sym. mesogenic arms. The phase-transition temperatures were overall higher for sym. (CN)AzoSnSAzo(CN) than for non-sym. (CN)AzoSnSCB. The difference in the mesogenic arm structures hardly influenced their mol. geometry or anisotropy in terms of entropy changes.

After consulting a lot of data, we found that this compound(111-24-0)Name: 1,5-Dibromopentane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application of 111-24-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Efficient synthesis and characterization of novel bis-heterocyclic derivatives and benzo-fused macrocycles containing oxazolone or imidazolone subunits. Author is Sanad, Sherif M. H.; Mekky, Ahmed E. M..

Bis(3-(arylthiomethyl)benzaldehydes), linked to aliphatic spacers via ethers, were prepared and used as key synthons for the bis(2-phenyloxazol-5(4H)-ones) I [R = 4-Me-PhS, 4-Cl-PhS, 4-NO2-PhS; R1 = 2-phenyloxazol-5(4H)-one-4-methylene] via their reaction with benzoylglycine. Bis(oxazol-5(4H)-ones) I were reacted with the appropriate aromatic or heterocyclic amines to afford a novel series of bis(2-phenylimidazol-4-ones) II [X = 4-Me-Ph, 4-Cl-Ph] and their related hybrids with benzo[d]thiazole and pyrimidine-2,4(1H,3H)-dione. Moreover, bis(oxazol-5(4H)-ones) I [R = 4-Me-PhS, 4-Cl-PhS; R1 = 2-phenyloxazol-5(4H)-one-4-methylene] reacted with (4-aminobenzoyl)glycine to afford bis[(4-(5-oxo-1H-imidazol-1-yl)benzoyl)glycine] derivatives II [R = 4-Me-PhS, 4-Cl-PhS; X = 4-C(O)NHCH2COOH-Ph] followed by their reaction with anisaldehyde gave corresponding bis(5-oxo-1H-imidazol-1-yloxazol-5(4H)-one) hybrids III [R2 = 4-(4-OMe-phenylmethylene)-oxazol-5(4H)-one]. Furthermore, bis(3-(arylthiomethyl)benzaldehydes) I [R = 4-Me-PhS, 4-Cl-PhS; R1 = CHO] were reacted with 2,2′-(terephthaloylbis(azanediyl))diacetic acid to give benzo-fused macrocycles IV [Y = O] containing oxazolone subunits which reacted with aromatic amines to give benzo-fused macrocycles IV [Y = 4-Me-Ph-N, 4-Cl-Ph-N] containing imidazolone subunits.

After consulting a lot of data, we found that this compound(111-24-0)Application of 111-24-0 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 111-24-0, is researched, SMILESS is BrCCCCCBr, Molecular C5H10Br2Journal, Article, Chemistry – A European Journal called Realization of an Asymmetric Non-Aqueous Redox Flow Battery through Molecular Design to Minimize Active Species Crossover and Decomposition, Author is Shrestha, Anuska; Hendriks, Koen H.; Sigman, Mathew S.; Minteer, Shelley D.; Sanford, Melanie S., the main research direction is asym redox flow battery mol design; active specie crossover decomposition minimization; anolyte decomposition; asymmetric; crossover; non-aqueous; redox flow batteries.Reference of 1,5-Dibromopentane.

This communication presents a mechanism-based approach to identify organic electrolytes for non-aqueous redox flow batteries (RFBs). Sym. flow cell cycling of a pyridinium anolyte and a cyclopropenium catholyte resulted in extensive capacity fade due to competing decomposition of the pyridinium species. Characterization of this decomposition pathway enabled the rational design of next-generation anolyte/catholyte pairs with dramatically enhanced cycling performance. Three factors were identified as critical for slowing capacity fade, separating the anolyte-catholyte in an asym. flow cell using an anion exchange membrane (AEM), moving from monomeric to oligomeric electrolytes to limit crossover through the AEM, and removing the basic carbonyl moiety from the anolyte to slow the protonation-induced decomposition pathway. Ultimately, these modifications led to a novel anolyte-catholyte pair that can be cycled in an AEM-separated asym. RFB for 96 h with > 95 % capacity retention at an open circuit voltage of 1.57 V.

After consulting a lot of data, we found that this compound(111-24-0)Reference of 1,5-Dibromopentane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zeslawska, Ewa; Kucwaj-Brysz, Katarzyna; Kincses, Annamaria; Spengler, Gabriella; Szymanska, Ewa; Czopek, Anna; Marc, Malgorzata Anna; Kaczor, Aneta; Nitek, Wojciech; Dominguez-Alvarez, Enrique; Latacz, Gniewomir; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Quality Control of 1,5-Dibromopentane.They published the article 《An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells》 about this compound( cas:111-24-0 ) in Bioorganic Chemistry. Keywords: arylpiperazinyl spiroimidazolidinedione preparation docking antitumor crystal multidrug resistance lymphoma; Crystal structure; Fluorene; Hydantoin; Multidrug resistance; P-glycoprotein (ABCB1); T-lymphoma. We’ll tell you more about this compound (cas:111-24-0).

A series of arylpiperazine derivatives of the 5-spiroimidazolidine-2,4-diones I/I·HCl (n = 3, 4, 5; R = Ph, Bn, 4-nitrophenyl, diphenylmethyl, 3-chlorophenyl), II (m = 1, 2; R1 = H, CF3) and III has been explored, including variations in the number of aromatic rings at position 5 and the length of the linker, as well as the kind and position of the linked arylpiperazine terminal fragment. Synthesis I/I·HCl and X-ray crystallog. studies for representative compounds I (n = 4; R = Bn), I·HCl (n = 3, R = Bn; n = 5, R = Ph) and II (m = 2; R1 = H (III)) have been performed. The ability to inhibit the tumor multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp, ABCB1) overexpressed in mouse T-lymphoma cells was investigated. The cytotoxic and antiproliferative actions of the compounds on both the reference and the ABCB1-overproducing cells were also examined The pharmacophore-based mol. modeling studies have been performed. ADMET properties in vitro of selected most active derivatives I (n = 4; R = 4-nitrophenyl) and I·HCl (n = 3, R = Ph; n = 4, R = diphenylmethyl (IV)) have been determined All compounds, excluding III, inhibited the cancer P-gp efflux pump with higher potency than that of reference verapamil. The spirofluorene derivatives with amine alkyl substituents at position 1, and the Me group at position 3 (I/I·HCl), occurred the most potent P-gp inhibitors in the MDR T-lymphoma cell line. In particular, compounds I·HCl (n = 3; R = 4-nitrophenyl) and IV were 100-fold more potent than verapamil. Crystallog.-supported pharmacophore-based SAR anal. has postulated specific structural properties that could explain this excellent cancer MDR-inhibitory action.

After consulting a lot of data, we found that this compound(111-24-0)Quality Control of 1,5-Dibromopentane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and characterization of cationic quaternary ammonium geminis (16-s-16) and their role in ninhydrin-[Cu(II)-His]+ reaction, published in 2021, which mentions a compound: 111-24-0, Name is 1,5-Dibromopentane, Molecular C5H10Br2, Related Products of 111-24-0.

Cationic quaternary ammonium gemini surfactants were synthesized by mixing N,N-dimethylcetylamine and α,ω-dibromoalkane. The synthesized products were characterized by C, H, N elemental and 1H NMR analyses. The critical micelle concentration (CMC) of these surfactants with and without additives was calculated by means of the conductivity technique. The role of the synthesized quaternary ammonium geminis in the reaction was investigated by a UV-vis spectroscopy. The rate constant (kψ) was determined at different gemini concentrations and plotted graphically as kψ vs. [16-s-16]. Addnl., the influence of other reaction parameters (viz., reactants, pH, and temperature) was investigated. The binding constants were also determined (KA for [Cu(II)-His]+ and KB for ninhydrin). The resulting kψ-[16-s-16] plot can be understood in terms of a pseudo-phase model of micelles.

Although many compounds look similar to this compound(111-24-0)Related Products of 111-24-0, numerous studies have shown that this compound(SMILES:BrCCCCCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Efficient synthesis of isosorbide-based polycarbonate with scalable dicationic ionic liquid catalysts by balancing the reactivity of the endo-OH and exo-OH.Formula: C5H10Br2.

In this study, a series of high-activity imidazole-based dicationic ionic liquids (DILs) were designed and prepared as efficient catalysts for balancing the reactivity between the endo-hydroxyl group (endo-OH) and the exo-hydroxyl group (exo-OH) of isosorbide (ISO) to synthesize high mol. weight poly(isosorbide carbonate) (PIC). Meanwhile, the thermal performance of PIC was precisely optimized by regulating the chain configuration. When the trace amounts (4.5 x 10-5 based on the ISO molar amount) of bis-(3-methyl-1-imidazole)-ethylene dibromide ([C2(Min)2][Br]2) were used, the weight average mol. weight (Mw) of PIC reached 98 700 g mol-1. It could be concluded from the results of the experiment and the stimulation that the high catalytic activity of DILs was attributed to the strong electrostatic interaction between the cation and the substrate and the effective balance of the reactivity of the endo-OH and the exo-OH. Furthermore, we found that the reduction of hydroxyl groups in the terminal groups and the increase of endo-endo (a1) structure in the repeating unit improved the thermal properties of PIC. Finally, 1H NMR, Fourier IR spectroscopy, and d. functional theory (DFT) calculations were used to verify the reaction process through anion and cation multi-site synergistic effect and a possible electrophilic-nucleophilic reaction mechanism was successfully obtained.

Although many compounds look similar to this compound(111-24-0)Formula: C5H10Br2, numerous studies have shown that this compound(SMILES:BrCCCCCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of tert-Butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: tert-Butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate, is researched, Molecular C11H21NO4, CAS is 389889-80-9, about Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis. Author is Carpenter, Joseph; Wu, Gang; Wang, Ying; Cook, Erica M.; Wang, Tao; Sitkoff, Doree; Rossi, Karen A.; Mosure, Kathy; Zhuo, Xiaoliang; Cao, Gary G.; Ziegler, Milinda; Azzara, Anthony V.; Krupinski, Jack; Soars, Matthew G.; Ellsworth, Bruce Alan; Wacker, Dean A..

Herein we report the discovery and preclin. biol. evaluation of 6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid, compound 1 (BMS-986318), a nonbile acid farnesoid X receptor (FXR) agonist. Compound 1 exhibits potent in vitro and in vivo activation of FXR, has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis. The overall profile of compound 1 supports its continued evaluation.

Although many compounds look similar to this compound(389889-80-9)Safety of tert-Butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate, numerous studies have shown that this compound(SMILES:O=C(N1CCC(CO)(O)CC1)OC(C)(C)C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis