Tag: M.W:200-300

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 6684-39-5, is researched, Molecular C5H3Cl2NO2S, about Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface, the main research direction is antidiabetic interaction coulombic interface glucokinase complex regulatory protein GKRP.SDS of cas: 6684-39-5.

The glucokinase regulatory protein (GKRP) plays an essential role in glucose homeostasis by acting as a competitive inhibitor of glucokinase (GCK) and triggering its localization to the hepatocyte nucleus upon glucose deprivation. Metabolites such as fructose 6-phosphate and sorbitol 6-phosphate promote assembly of the GCK-GKRP complex, whereas fructose 1-phosphate and functionalized piperazines with potent in vivo antidiabetic activity disrupt the complex. Here, we establish the mol. basis by which these natural and synthetic ligands modulate the GCK-GKRP interaction. We demonstrate that a small-mol. disruptor of the protein-protein interaction utilizes a two-step conformational selection mechanism to associate with a rare GKRP conformation constituting 3% of the total population. Conformational heterogeneity of GKRP is localized to the N-terminus and deleting this region eliminates the ability of sorbitol 6-phosphate to promote the GCK-GKRP interaction. Stabilizing ligands favor an extended N-terminus, which sterically positions two arginine residues for optimal coulombic interaction with a pair of carboxylate side chains from GCK. Conversely, disruptors promote a more compact N-terminus in which an interfacial arginine residue is stabilized in an unproductive orientation through a cation-π interaction with tyrosine 75. Eliminating the ability to sample this binding impaired conformation enhances the intrinsic inhibitory activity of GKRP. Elucidating the mol. basis of ligand-mediated control over the GCK-GKRP interaction is expected to impact the development and future refinement of therapeutic agents for diabetes and cardiovascular disease, which result from improper GKRP regulation of GCK.

Although many compounds look similar to this compound(6684-39-5)SDS of cas: 6684-39-5, numerous studies have shown that this compound(SMILES:ClC1=NC=C(C=C1)[S](=O)(=O)Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C5H10Br2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Synthesis of ETS-10-like vanadosilicates using 2,6-dimethylpiperidinium cation derivatives as organic templates.

Systematic vanadosilicate syntheses were performed using derivatives of 2,6-dimethylpiperidine as organic structure-directing agents (SDAs). Physicochem. analyses of the vanadosilicate materials obtained were carried out by X-ray diffraction (XRD), Raman spectroscopy, IR spectroscopy, UV-visible (UV-Vis) spectroscopy, and solid-state NMR spectroscopy (29Si and 51V MAS NMR). The exptl. results indicated that the presence of the organic templates had different effects on the final phases of the synthesized vanadosilicates. The XRD results showed that 1,1,2,6-tetramethylpiperidinium (SDA 1) favored synthesis of the known AM-6 vanadosilicates, isostructural to the ETS-10 titanosilicate, while the other organic templates 1,1-diethyl-2,6-dimethylpiperidinium (SDA 2), 6,10-dimethyl-5-azoniaspiro[4.5]decane (SDA 3), and 1,5-dimethyl-6-azoniaspiro[5.5]undecane (SDA 4) directed the formation of vanadosilicates with different phases, such as EVS-10. Strong Raman bands at 870 and 1035 cm-1 indicated vibrational modes associated with the highly sym. vanadia octahedra. Chem. shifts at -96 ppm (29Si MAS NMR), -610, and -570 ppm (51V MAS NMR) provided further evidence of the incorporation of vanadium into the structures of the vanadosilicates prepared using these novel derivatives of 2,6-dimethylpiperidinium cations as SDAs.

Compounds in my other articles are similar to this one(1,5-Dibromopentane)Computed Properties of C5H10Br2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Product Details of 6684-39-5. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloro-5-pyridinesulfonyl chloride, is researched, Molecular C5H3Cl2NO2S, CAS is 6684-39-5, about A reversed sulfonamide series of selective RORc inverse agonists. Author is van Niel, Monique B.; Fauber, Benjamin P.; Cartwright, Matthew; Gaines, Simon; Killen, Jonathan C.; Rene, Olivier; Ward, Stuart I.; de Leon Boenig, Gladys; Deng, Yuzhong; Eidenschenk, Celine; Everett, Christine; Gancia, Emanuela; Ganguli, Arunima; Gobbi, Alberto; Hawkins, Julie; Johnson, Adam R.; Kiefer, James R.; La, Hank; Lockey, Peter; Norman, Maxine; Ouyang, Wenjun; Qin, Ann; Wakes, Nicole; Waszkowycz, Bohdan; Wong, Harvey.

The identification of a new series of RORc inverse agonists is described. Comprehensive structure-activity relationship studies of this reversed sulfonamide series identified potent RORc inverse agonists in biochem. and cellular assays which were also selective against a panel of nuclear receptors. The work has contributed a compound that may serve as a useful in vitro tool to delineate the complex biol. pathways involved in signaling through RORc. An x-ray cocrystal structure of an analog with RORc has also provided useful insights into the binding interactions of the new series.

Compounds in my other articles are similar to this one(2-Chloro-5-pyridinesulfonyl chloride)Product Details of 6684-39-5, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,5-Dibromopentane( cas:111-24-0 ) is researched.Recommanded Product: 1,5-Dibromopentane.Mezzetta, Andrea; Guglielmero, Luca; Mero, Angelica; Tofani, Giorgio; D’Andrea, Felicia; Pomelli, Christian Silvio; Guazzelli, Lorenzo published the article 《Expanding the Chemical Space of Benzimidazole Dicationic Ionic Liquids》 about this compound( cas:111-24-0 ) in Molecules. Keywords: benzimidazole dicationic ionic liquid thermal stability cyclic voltammetry; benzimidazole; cyclic voltammetry; dicationic ionic liquids; green solvents; ionic liquids; thermal behavior; thermal stability. Let’s learn more about this compound (cas:111-24-0).

Benzimidazole dicationic ionic liquids (BDILs) have not yet been widely explored in spite of their potential. Therefore, two structurally related families of BDILs, paired with either bromide or bistriflimide anions and bearing alkyl spacers ranging from C3 to C6, have been prepared Their thermal properties have been studied by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC), while their elec. properties have been assessed by cyclic voltammetry (CV). TG anal. confirmed the higher stability of the bistriflimide BDILs over the bromide BDILs, with minor variation within the two families. Conversely, DSC and CV allowed for ascertaining the role played by the spacer length. In particular, the thermal behavior changed dramatically among the members of the bistriflimide family, and all three possible thermal behavior types of ILs were observed Furthermore, cyclic voltammetry showed different electrochem. window (C3(C1BenzIm)2/2Tf2N < C4(C1BenzIm)2/2Tf2N, C5(C1BenzIm)2/2Tf2N < C6(C1BenzIm)2/2Tf2N) as well as a reduction peak potential, shape, and intensity as a function of the spacer length. The results obtained highlight the benefit of accessing a more structurally diverse pool of compounds offered by dicationic ILs when compared to the parent monocationic ILs. In particular, gains are to be found in the ease of fine-tuning their properties, which translates in facilitating further investigations toward BDILs as designer solvents and catalysts. Compounds in my other articles are similar to this one(1,5-Dibromopentane)Recommanded Product: 1,5-Dibromopentane, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Safety of 1,5-Dibromopentane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,5-Dibromopentane, is researched, Molecular C5H10Br2, CAS is 111-24-0, about Synthesis and characterization of new gemini surfactants derived from imidazole and indole and study their efficiency as dispersible and biologically effective materials. Author is Al. Ibadi, Ghufran A. M.; Al. Asadi, Mohanad J. K..

In the present study, two sets of stimulants for the gemini surfactants derived from imidazole and indole were prepared, which contain a terminal chain containing eight carbon atoms and a separation between the two heads and two tails of the surface activating substance called 1, 5-di bromo pentane. The prepared compounds were characterized using the FTIR and 1HNMR. The value of the critical micellization concentration (CMC) was calculated using elec. conductivity, as well as the value of the balance system between hydrophilic and lipophilic groups (HLB) to find out the appropriate application for them. The effectiveness of dispersion of oil spots in (oil/water) emulsions and biol. activity on specific types of bacteria have also been studied.

Compounds in my other articles are similar to this one(1,5-Dibromopentane)Safety of 1,5-Dibromopentane, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,5-Dibromopentane( cas:111-24-0 ) is researched.Computed Properties of C5H10Br2.Liang, Yan; He, Dian; Zhou, Deshun; Li, Junshuai; Tang, Lei; Wang, Zhen published the article 《Synthesis, Antibacterial and Pharmacokinetic Evaluation of Novel Derivatives of Harmine N9-Cinnamic Acid》 about this compound( cas:111-24-0 ) in Molecules. Keywords: harmine cinnamic acid derivative antibacterial pharmacokinetic evaluation; antibacterial activity; harmine; pharmacokinetics; synthesis. Let’s learn more about this compound (cas:111-24-0).

A series of 16 new derivatives of harmine N9-Cinnamic acid were synthesized and fully characterized using NMR and MS. The in vitro antibacterial evaluation revealed that most of the synthesized harmine derivatives displayed better antibacterial activities against Gram-pos. strains (S. aureus, S. albus and MRSA) than Gram-neg. strains (E. coli and PA). In particular, compound 3c showed the strongest bactericidal activity with a min. inhibitory concentration of 13.67 μg/mL. MTT assay showed that compound 3c displayed weaker cytotoxicity than harmine with IC50 of 340.30, 94.86 and 161.67 μmol/L against WI-38, MCF-7 and HepG2 cell lines, resp. The pharmacokinetic study revealed that the distribution and elimination of 3c in vivo were rapid in rats with an oral bioavailability of 6.9%.

Compounds in my other articles are similar to this one(1,5-Dibromopentane)Computed Properties of C5H10Br2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, crystal structure and evaluation of four carbazole-coumarin hybrids as multifunctional agents for the treatment of Alzheimer’s disease, published in 2020-06-05, which mentions a compound: 111-24-0, Name is 1,5-Dibromopentane, Molecular C5H10Br2, Category: chiral-nitrogen-ligands.

Coupling of two distinct pharmacophores carbazole and coumarin endowed with different biol. properties afforded four hybrid compounds I [n = 3,5] and II. The structures of the carbazole-coumarin hybrids I and II were characterized by FT-IR, NMR, HRMS and single-crystal X-ray diffraction studies. All of these compounds I and II exhibited significant acetylcholinesterase inhibitory activities. Among them, compound II [n = 5] exhibited the best inhibition activity with IC50 of 3.75μM for acetylcholinesterase from elec. eel and 70.51μM for human recombinant acetylcholinesterase. Moreover, the compound I [n = 3] was showed the best antioxidant activity. The docking studies demonstrated that compound II [n = 5] could interacted with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. These attributed imply carbazole-coumarin hybrids as multifunctional agents for the Alzheimer’s disease treatment.

In some applications, this compound(111-24-0)Category: chiral-nitrogen-ligands is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Bhattarai, Ajaya; Saha, Bidyut; Jaffari, Zeeshan Haider; Rub, Malik Abdul; Alghamdi, Yousef G.; Kumar, Dileep published the article 《Analysis of interaction between glutamic acid and ninhydrin in the presence of acetate buffer solvent: Impact of gemini (twin-headed) surfactants》. Keywords: glutamic acid ninhydrin acetate buffer gemini surfactant.They researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Recommanded Product: 111-24-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:111-24-0) here.

This study analyses the impact of twin-headed gemini surfactants on the interaction between glutamic acid (Glu) and a ninhydrin (Nin) in an acetate buffer. Analyses were observed using a UV-vis spectrophotometer and values of absorbance were recorded at fixed time intermissions. The impact of parameters such as pH, temperature, [Glu], and [Nin] was examined on reaction in gemini surfactants. Using a conductometric technique, elec. conductivities of pure geminis and their mixed systems were noted. Using these data, thus, cmc values of pure geminis and their mixed system were measured. By varying different parameters, the rate constant (kψ-value) was evaluated on finishing each kinetic run using a computer-based procedure. The study showed that twin-headed gemini surfactants demonstrated an excellent impact on the titled reaction over the aqueous system although 16-4-16 catalyzed the study more among geminis and followed the abilities to catalyze at each concentration as 16-4-16 > 16-5-16 > 16-6-16. Our goal was to assess the impact of varied gemini surfactants on rate constant and thus, a pseudo-phase model for micellar activity was applied. A low pos. value of ΔH# with a large neg. ΔS# was obtained in geminis than for aqueous solutions A probable reaction mechanism is discussed.

In some applications, this compound(111-24-0)Recommanded Product: 111-24-0 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Boothello, Rio S.; Sankaranarayanan, Nehru Viji; Afosah, Daniel K.; Karuturi, Rajesh; Al-Horani, Rami A.; Desai, Umesh R. researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).COA of Formula: C5H10Br2.They published the article 《Studies on fragment-based design of allosteric inhibitors of human factor XIa》 about this compound( cas:111-24-0 ) in Bioorganic & Medicinal Chemistry. Keywords: fragment based drug design coagulation factors anticoagulants heparins allosterism; Allosterism; Anticoagulants; Coagulation factors; Fragment-based drug design; Heparins. We’ll tell you more about this compound (cas:111-24-0).

Human factor XIa (hFXIa) has emerged as an attractive target for development of new anticoagulants that promise higher level of safety. Different strategies have been adopted so far for the design of anti-hFXIa mols. including competitive and non-competitive inhibition. Of these, allosteric dysfunction of hFXIa′s active site is especially promising because of the possibility of controlled reduction in activity that may offer a route to safer anticoagulants. In this work, we assess fragment-based design approach to realize a group of novel allosteric hFXIa inhibitors. Starting with our earlier discovery that sulfated quinazolinone (QAO) bind in the heparin-binding site of hFXIa, we developed a group of two dozen dimeric sulfated QAOs with intervening linkers that displayed a progressive variation in inhibition potency. In direct opposition to the traditional wisdom, increasing linker flexibility led to higher potency, which could be explained by computational studies. Sulfated QAO 19S(I) was identified as the most potent and selective inhibitor of hFXIa. Enzyme inhibition studies revealed that 19S utilizes a non-competitive mechanism of action, which was supported by fluorescence studies showing a classic sigmoidal binding profile. Studies with selected mutants of hFXIa indicated that sulfated QAOs bind in heparin-binding site of the catalytic domain of hFXIa. Overall, the approach of fragment-based design offers considerable promise for designing heparin-binding site-directed allosteric inhibitors of hFXIa.

In some applications, this compound(111-24-0)COA of Formula: C5H10Br2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,5-Dibromopentane(SMILESS: BrCCCCCBr,cas:111-24-0) is researched.Reference of 2-Aminoquinazolin-4(3H)-one. The article 《Design, synthesis and biological evaluation of new carbazole-coumarin hybrids as dual binding site inhibitors of acetylcholinesterase》 in relation to this compound, is published in Journal of Molecular Structure. Let’s take a look at the latest research on this compound (cas:111-24-0).

Twelve carbazole-coumarin hybrids I (n = 2, 3, 4, 5; R = H, Me) and II were synthesized and biol. evaluated as dual binding site acetylcholinesterase inhibitors. The compound II (n = 3) had the crystal system of triclinic and the space group of P-1. The cholinesterase inhibitory activity of synthesized compounds I and II was measured using colorimetric Ellman’s method. Compound I [n = 5; R = Me] (III) exhibited good acetylcholinesterase (AChE) inhibitory activity (IC50 value of 6.72μM) and a high selectivity over butyrylcholinesterase (BuChE). Compound II (n = 4) showed the best BuChE inhibitory activity with the IC50 of 0.50μM. The SAR studies revealed that the linker length played a crucial role in determining AChE inhibitory activity and the structure of the coumarin moieties affected the BuChE-inhibition activities of the hybrids. Mol. docking study of compound III indicated that it interacts with the crucial amino acids present at the catalytic active site and peripheral anionic site of AChE. Compound III would be a promising drug candidate to treat AD as a selective and dual binding site inhibitor of AChE.

In some applications, this compound(111-24-0)Formula: C5H10Br2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis