Tag: M.W=400-500

Computed Properties of C30H21P. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Palladium-Catalyzed Silacyclization of (Hetero)Arenes with a Tetrasilane Reagent through Twofold C-H Activation. Author is Wang, Dingyi; Li, Mingjie; Chen, Xiangyang; Wang, Minyan; Liang, Yong; Zhao, Yue; Houk, Kendall N.; Shi, Zhuangzhi.

The use of an operationally convenient and stable silicon reagent (octamethyl-1,4-dioxacyclohexasilane, ODCS) for the selective silacyclization of (hetero)arenes via twofold C-H activation is reported, giving oxadisilole-annelated indole, carbazoles and arene phosphine derivatives This method is compatible with N-containing heteroarenes such as indoles and carbazoles of varying complexity. The ODCS reagent can also be utilized for silacyclization of other types of substrates, including tertiary phosphines and aryl halides. A series of mechanistic experiments and d. functional theory (DFT) calculations were used to investigate the preferred pathway for this twofold C-H activation process.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Polymerization of functionalized norbornenes: Trends and reactivity ratios, published in 2003, which mentions a compound: 3411-48-1, Name is Tri(naphthalen-1-yl)phosphine, Molecular C30H21P, Application In Synthesis of Tri(naphthalen-1-yl)phosphine.

The polymerization of functionalized norbornenes by the known Pd(II) polymerization catalyst, R3P-(1,5-cyclooctadiene)Pd(Me)Cl, was examined Steric and electronic effects of various phosphine ligands on the polymerization activity were examined in relation to the norbornene monomers 5-butyl-2-norbornene (Butyl-NB), 5-Et ester-2-norbornene (EtEster-NB) and 5-methylacetate-2-norbornene (MeOAc-NB) and their exo/ endo preference. In all the polymerizations, the exo isomer was preferentially polymerized The Butyl-NB homopolymerization rate was fastest for sterically bulky phosphines while the EtEster-NB and MeOAc-NB homopolymerization rates were fastest for weakly basic triarylphosphines. The rate of polymerization in the copolymerizations of Butyl-NB and EtEster-NB or MeOAc-NB was faster with weakly basic triarylphosphines. Polymerizations with MeOAc-NB were slower than comparable polymerizations with EtEster-NB due to more facile coordination of the carbonyl functionality. This was confirmed by comparing the rate of Butyl-NB polymerization in the copolymerizations and in the presence of the corresponding norbornane. Reactivity ratios the various catalysts were calculated by the sum-of-squares space method.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Molecular Catalysis called Composition of catalyst resting states of hydroformylation catalysts derived from bulky mono-phosphorus ligands, rhodium dicarbonyl acetylacetonate and syngas, Author is How, Rebecca C.; Dingwall, Paul; Hembre, Robert T.; Ponasik, James A.; Tolleson, Ginette S.; Clarke, Matthew L., which mentions a compound: 3411-48-1, SMILESS is C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2, Molecular C30H21P, Product Details of 3411-48-1.

The paper describes the composition of the resting states of several catalysts for alkene hydroformylation derived from bulky monophosphorus ligands. The results presented assess how bulky ligands compete with CO for the Rh, and hence the role of ‘unmodified’ catalysts in alkene hydroformylation in the presence of these ligands. High Pressure Infra-Red (HPIR) spectroscopy was carried out at the Rh and syngas concentrations typically used during catalysis experiments These HPIR studies revealed that two ligands previously studied in Rh-catalyzed hydroformylation react with [Rh(acac)(CO)2] and H2/CO to give the unmodified Rh cluster, [Rh6(CO)16], as the only detectable species. Both less bulky phosphoramidites, and 1,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane, however, do not show [Rh6(CO)16], and hence catalysis proceeds by purely ligand modified species under normal conditions. In the case of the Rh/phosphaadamantane catalysts, anecdotal evidence that this only forms a particularly useful catalyst above a certain pressure threshold can be understood in terms of how the catalyst composition varies with pressure. The ligands discussed have all been assessed in the hydroformylation of propene to sep. their innate branched selectivity from their ability to isomerize higher alkenes to internal isomers.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Terao, Yoshito; Nomoto, Michiyo; Satoh, Tetsuya; Miura, Masahiro; Nomura, Masakatsu published the article 《Palladium-catalyzed dehydroarylation of triarylmethanols and their coupling with unsaturated compounds accompanied by C-C bond cleavage》. Keywords: triarylmethanol dehydroarylation palladium phosphine; diaryl ketone preparation; arene preparation; alkyne triarylmethanol dehydroarylation hydroarylation palladium phosphine; arylalkenes stereoselective preparation; palladium phosphine dehydroarylation catalyst.They researched the compound: Tri(naphthalen-1-yl)phosphine( cas:3411-48-1 ).Category: chiral-nitrogen-ligands. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3411-48-1) here.

Triarylmethanols were effectively dehydroarylated and reacted with some unsaturated compounds by using an appropriate palladium catalyst system such as Pd(OAc)2-P(1-Nap)3 to give the corresponding arenes and hydroarylation products, e.g., I, resp., along with diaryl ketones.

Here is just a brief introduction to this compound(3411-48-1)Category: chiral-nitrogen-ligands, more information about the compound(Tri(naphthalen-1-yl)phosphine) is in the article, you can click the link below.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Computed Properties of C30H21P. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Naphthyne: Osmium and Ruthenium Cluster Derivatives.

Reaction of the 1-naphthyl derivatives E(1-C10H7)3 (E = P, As) with M3(CO)12 (M = Ru, Os) affords naphthyne complexes M3(CO)8(μ-H)2[μ3-η4-(C10H7)2E(C10H5)] (shown as I; M = Os, Ru; E = As, P; R = 1-naphthyl 5-8) in moderate to good yield, via double metalation of the unsubstituted aromatic ring. Metalation of the substituted aromatic ring results in one complex, Os3(CO)9(μ-H)[(C10H7)2P(C10H6)]. Cleavage of an As-naphthyl bond affords a low yield of the naphthyne complex Ru4(CO)10(μ-CO)[μ4-As(C10H7)][μ4-C10H6] (11), in which the aryne ring is at an angle of 75° to the Ru4 plane and acts as a four-electron donor, making 11 formally electron deficient. Crystals of 5 are monoclinic, with a 25.746(1), b 9.688(2), c 33.521(1) Å, β 108.647(3)°, Z = 8, and space group C2/c. Those of 11 are triclinic, with a 11.433(3), b 14.746(2), c 9.958(1) Å, α 96.81(1), β 102.34(2), γ 78.69(2)°, Z = 2, space group P1̅. The structures were solved by the Patterson method and were refined by full-matrix least-squares procedures to R = 0.033 and 0.030 (Rw = 0.031 and 0.028) for 5308 and 4933 reflections with I ≥ 3σ(I), resp.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Svahn, Noora; Moro, Artur J.; Roma-Rodrigues, Catarina; Puttreddy, Rakesh; Rissanen, Kari; Baptista, Pedro V.; Fernandes, Alexandra R.; Lima, Joao Carlos; Rodriguez, Laura researched the compound: Tri(naphthalen-1-yl)phosphine( cas:3411-48-1 ).Quality Control of Tri(naphthalen-1-yl)phosphine.They published the article 《The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes》 about this compound( cas:3411-48-1 ) in Chemistry – A European Journal. Keywords: gold ethynylaniline acetylide phosphine complex preparation antitumor agent; cytotoxicity selectivity gold ethynylaniline acetylide phosphine complex; crystal structure gold ethynylaniline acetylide phosphine complex; mol structure gold ethynylaniline acetylide phosphine complex; X-ray diffraction; antitumor agents; apoptosis; biological activity; gold. We’ll tell you more about this compound (cas:3411-48-1).

A series of 4-ethynylaniline gold(I) complexes H2NC6H4CCAuL containing monophosphines (2, L = 1,3,5-triaza-7-phosphaadamantane, pta; 3, L = 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane; 4-6, L = tri-1-naphthylphosphine, PPh3, PEt3), diphosphines [7, L = 1/2 bis(diphenylphosphino)acetylene (dppa), 8, 1/2 L = trans-1,2-bis(diphenylphosphino)ethene (dppet); 9, 1/2 L = dppe; 10, 1/2 L = dppp] ligands have been synthesized and their efficiency against tumor cells evaluated. The cytotoxicity of complexes 2-10 was evaluated in human colorectal (HCT116) and ovarian (A2780) carcinoma as well as in normal human fibroblasts. All the complexes showed a higher antiproliferative effect in A2780 cells, with the cytotoxicity decreasing in the following order 5 > 6 = 9 = 10 > 8 > 2 > 4 > 7 > 3. Complex 4 stands out for its very high selectivity towards ovarian carcinoma cells (IC50=2.3 μM) compared with colorectal carcinoma and normal human fibroblasts (IC50>100 μM), which makes this complex very attractive for ovarian cancer therapy. Its cytotoxicity in these cells correlates with the induction of the apoptotic process and an increase of intracellular reactive oxygen species (ROS). The effects of the nuclearity, rigidity, and solubility of these complexes on their biol. activity were also analyzed. X-ray crystal structure determination allowed the identification of short N-H…π contacts as the main driving forces for the three-dimensional packing in these mols.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Category: chiral-nitrogen-ligands. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Hydrogen transfer. XXVII. Influence of ligands in tertiary phosphines on the rate of hydrogenation of olefines with rhodium complexes in homogenous solution.

The rate of homogeneous hydrogenation r of 1-hexene in the presence of various tertiary phosphine-RhCl complexes as catalysts is determined at 25-30° and discussed in relation to the substituents in the phosphines. The phosphine-Rh(I) complexes are prepared from μ-dichlorobis(1,5-hexadiene)dirhodium(I) and tertiary phosphines under H. Maximum r-values are observed for 1:2.2 Rh-phosphine molar ratio. Para substituents with donor quality in PPh3 increase r, but electrophilic substituents in the same position decrease r. Aliphatic ligands in the tertiary phosphines decrease r; an increase of r is only observed for bulk ligands, e.g., in the case of MePPhBu-tert.

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Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis, the main research direction is phosphonium salts visceral Leishmaniasis pharmacokinetics antimonials antileishmanial.Quality Control of Tri(naphthalen-1-yl)phosphine.

We report the discovery of new 4-hydroxyphenyl phosphonium salt derivatives active in the submicromolar range (EC50 from 0.04 to 0.28μM, SI > 10) against the protozoan parasite Leishmania donovani. The pharmacokinetics and in vivo oral efficacy of compound 1 [(16-(2,4-dihydroxyphenyl)-16-oxohexadecyl)triphenylphosphonium bromide] in a mouse model of visceral leishmaniasis were established. Compound 1 reduced the parasite load in spleen (98.9%) and liver (95.3%) of infected mice after an oral dosage of four daily doses of 1.5 mg/kg. Mode of action studies showed that compound 1 diffuses across the plasma membrane, as designed, and targets the mitochondrion of Leishmania parasites. Disruption of the energetic metabolism, with a decrease of intracellular ATP levels as well as mitochondrial depolarization together with a significant reactive oxygen species production, contributes to the leishmanicidal effect of 1. Importantly, this compound was equally effective against antimonials and miltefosine-resistant clin. isolates of Leishmania infantum, indicating its potential as antileishmanial lead.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Interface chemistry of organophosphorus compounds. II. Spreading behavior of aromatic, mixed aromatic-n-aliphatic, aromatic-cycloaliphatic, or aliphatic-cycloaliphatic phosphines.SDS of cas: 3411-48-1.

The aromatic phosphines, PRR21 (I), where R, R1 = Ph, α- or β-naphthyl, p-biphenylyl, or anthryl), or their oxides do not form monolayers at the air/H2O interface, due to the electron withdrawing character of the aromatic rings, which makes the free electron pair of P unavailable for solvation. The introduction of Me as an electron repelling group, as in tri-p-tolylphosphine, leads to the formation of multimol. films. The mol. area of the nonspreading I (R = R1 = Ph) (Ia) was determined from the increase in area caused by the addition of Ia to the spreading I (R = R1 = n-C8H17). The mol. of Ia is pyramidal in the mixed films. The spreading properties of mixed I, where R, R1 = aliphatic or aromatic., are a combination of the properties of the individual I, where R = R1 = aliphatic or aromatic. I (R = R1 = cyclohexyl) (Ib) forms real gas-analogous films. The observed mol. area is smaller than the calculated area, due to the bulky structure of the cyclohexyl groups. Replacement of 1-2 cyclohexyl groups with aliphatic or aromatic groups results in improvement or deterioration resp. of the spreading properties of the phosphines.

From this literature《Interface chemistry of organophosphorus compounds. II. Spreading behavior of aromatic, mixed aromatic-n-aliphatic, aromatic-cycloaliphatic, or aliphatic-cycloaliphatic phosphines》,we know some information about this compound(3411-48-1)SDS of cas: 3411-48-1, but this is not all information, there are many literatures related to this compound(3411-48-1).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3411-48-1, is researched, SMILESS is C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2, Molecular C30H21PJournal, Russian Journal of Organic Chemistry called Polarity and Conformational Analysis of Tri(1-naphthyl)phosphine, Tri(2-naphthyl)phosphine, and Their Chalcogenides, Author is Kuznetsova, A. A.; Chachkov, D. V.; Belogorlova, N. A.; Kuimov, V. A.; Malysheva, S. F.; Vereshchagina, Ya. A., the main research direction is naphthylphosphine chalcogenide preparation conformational analysis DFT polarity dipole moment; phosphine naphthyl chalcogenide preparation conformational analysis DFT polarity.Synthetic Route of C30H21P.

Abstract: The polarity and structure of tri(1- or 2-naphthyl)phosphines and their chalcogenides were determined by the methods of dipole moments, IR spectroscopy, and DFT quantum-chem. calculations at the B3PW91/6-311++G(df,p) level of theory. In solution, tri(1-naphthyl)phosphine prefers a single conformer with a gauche,gauche,gauche orientation of the substituents at the P. Tri(2-naphthyl)phosphine, as well as both phosphine chalcogenides exist as equilibrium mixtures of several forms with a propeller arrangement of the substituents and a cis or gauche orientation of the Csp2-Csp2 and P=X (X = LEP, O, S, Se) bonds.

From this literature《Polarity and Conformational Analysis of Tri(1-naphthyl)phosphine, Tri(2-naphthyl)phosphine, and Their Chalcogenides》,we know some information about this compound(3411-48-1)Synthetic Route of C30H21P, but this is not all information, there are many literatures related to this compound(3411-48-1).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis