Tag: M.W=400-500

Computed Properties of C30H21P. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Regioselective hydroformylation of vinyl acetate catalyzed by rhodium complex of naphthyl-based monodentate bulky phosphine and phosphite ligands. Author is Dabbawala, Aasif A.; Bajaj, Hari C.; Rao, Ganga V. S.; Abdi, Sayed H. R..

The hydroformylation of vinyl acetate was carried out using rhodium complex of naphthyl-based monodentate bulky phosphine and phosphite ligands. All the naphthyl-based ligands favored the formation of desire branched aldehyde. High turnover frequency with excellent regioselectivity to branched aldehyde and high selectivity to aldehyde were observed with bulky phosphite ligands. The effect of partial pressure of CO and H2, concentration of vinyl acetate, stirring rate and solvents on the hydroformylation of vinyl acetate catalyzed by Rh/bulky phosphite were examined precisely in order to improve the catalytic activity and selectivity. In contrast to conventional organic solvents, the significant influence on the activity and selectivity was observed in organic carbonates ( green’ solvent) particularly in propylene carbonate (PC). The PC/catalyst system could be recycled without significant loss of activity and selectivity.

There is still a lot of research devoted to this compound(SMILES：C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2)Computed Properties of C30H21P, and with the development of science, more effects of this compound(3411-48-1) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Application In Synthesis of Tri(naphthalen-1-yl)phosphine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Enantioselective synthesis of β2-amino acids using rhodium-catalyzed hydrogenation. Author is Hoen, Rob; Tiemersma-Wegman, Theodora; Procuranti, Barbara; Lefort, Laurent; de Vries, Johannes G.; Minnaard, Adriaan J.; Feringa, Ben L..

A series of protected β2-dehydroamino acids has been prepared in three steps from com. available starting materials in good yields. These were used as substrates in rhodium-catalyzed asym. hydrogenation using a mixed ligand system of monodentate phosphoramidites and phosphines. Optimization of the catalyst structure was achieved by high throughput experimentation. High enantioselectivities were obtained (up to 91%) with full conversion for a number of β-amino acids.

There is still a lot of research devoted to this compound(SMILES：C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2)Application In Synthesis of Tri(naphthalen-1-yl)phosphine, and with the development of science, more effects of this compound(3411-48-1) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Qin, Changming; Chen, Jiuxi; Wu, Huayue; Cheng, Jiang; Zhang, Qiang; Zuo, Bing; Su, Weike; Ding, Jinchang published the article 《One-pot synthesis of diaryl ketones from aldehydes via palladium-catalyzed reaction with aryl boronic acids》. Keywords: aromatic aldehyde aryl boronic acid cross coupling palladium; benzophenone derivative preparation; diaryl ketone preparation; palladium cross coupling catalyst.They researched the compound: Tri(naphthalen-1-yl)phosphine( cas:3411-48-1 ).Electric Literature of C30H21P. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3411-48-1) here.

A Pd-catalyzed coupling-type reaction of aldehydes and organoboronic acids was achieved in the presence of P(1-nap)3, using Cs2CO3 in toluene, providing diaryl ketones with yields ranged from moderate to excellent. The efficiency of this reaction was demonstrated by the compatibility with nitro, cyano, trifluoromethyl, fluoro and chloro groups. Moreover, the rigorous exclusion of air/moisture is not required in these transformations.

There is still a lot of research devoted to this compound(SMILES：C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2)Electric Literature of C30H21P, and with the development of science, more effects of this compound(3411-48-1) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Reference of Tri(naphthalen-1-yl)phosphine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Palladium-catalyzed vinylic substitution with highly activated aryl halides. Author is Ziegler, Carl B. Jr.; Heck, Richard F..

Aryl bromides with strongly electron-donating substituents generally do not undergo the Ph3P-Pd(OAc)2-catalyzed vinylic substitution reaction in acceptable yields. Competing formation of tetraarylphosphonium salts from the aryl bromide and, in some cases, the reduction of the aryl bromide to the arene occur. Significant improvements in yield are obtained when (o-MeC6H4)3P is used instead of Ph3P. As good or even better results are obtained using the corresponding aryl iodide instead of the bromide and using Pd(OAc)2 without a phosphine as the catalyst.

There is still a lot of research devoted to this compound(SMILES：C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2)Reference of Tri(naphthalen-1-yl)phosphine, and with the development of science, more effects of this compound(3411-48-1) can be discovered.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Phosphines and phosphine sulfides containing highly condensed aromatic groups》. Authors are Tefteller, Wilburn Jr.; Zingaro, Ralph A.; Isbell, A. F..The article about the compound:Tri(naphthalen-1-yl)phosphinecas:3411-48-1,SMILESS:C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2).Synthetic Route of C30H21P. Through the article, more information about this compound (cas:3411-48-1) is conveyed.

The preparation and properties of 4 new phosphines and 6 new phosphine sulfides are reported. Preparation of the phosphines is accomplished by condensation of a P trihalide, or substituted halide with the aryllithium compound in an inert atm. The sulfides are prepared by refluxing the phosphine with S in an appropriate solvent. The phosphines and sulfides are colorless solids.

Here is a brief introduction to this compound(3411-48-1)Synthetic Route of C30H21P, if you want to know about other compounds related to this compound(3411-48-1), you can read my other articles.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Steric hindrance in the addition of halogens to triaryl phosphites》. Authors are Anschutz, Ludwig; Kraft, Horst; Schmidt, Kurt.The article about the compound:Tri(naphthalen-1-yl)phosphinecas:3411-48-1,SMILESS:C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2).Related Products of 3411-48-1. Through the article, more information about this compound (cas:3411-48-1) is conveyed.

2,4,1-Br2C10H5OH (20 g.) and 3 g. of PCl3, heated 18 hrs. on the water bath and the product taken up in 100 cc. xylene at 100°, give about 20% of tri(2,4-dibromo-1-naphthyl)phosphite (I), m. 289°; a suspension in CCl4 does not add Cl or Br (in 48 hrs.). The 1,6,2-isomer of I, crystallized from CCl4-Et2O, m. 245° (15% yield); this also does not add Cl or Br. 1,6,2-Br2C10H5OH and PCl5, heated 6 hrs. at 140-50°, give a yellow-brown smear which loses HCl in the air; that this is tri(1,6-dibromo-2-naphthyl) phosphite dichloride follows from the reaction with boiling H2O for several hrs., which yields the phosphate, m. 200-1° (decomposition). 1-C10H7OH (22 g.) and 7 g. PCl3, heated 12 hrs. at 75-100°, give 45-50% of tri(1-naphthyl)phosphite (II), very hygroscopic, m. 91° (crystallized from xylene and washed with Et2O); in Et2O it absorbs Cl (2 hrs.) to give the dichloride, light green very hygroscopic liquid, purified by treatment with C6H6 and Et2O; hydrolysis gives the phosphate, m. 145°; dibromide, ruby-red, very hygroscopic oil. The 2-isomer of II m. 94° (crystallized from xylene and Et2O); dichloride, yellow oil, hydrolyzed to the phosphate, m. 110-11°; dibromide, brownish red oil. 1-C10H7MgBr and PCl3 in Et2O give 30-5% of tri(1-naphthyl)phosphine (III), m. 282° (from dioxane); it forms a complex with 1 mol. CHCl3, m. 262° (lost on heating in vacuo at 98°) and with 1 mol. of CCl4. The dichloride of III has been obtained only as the complex with 1 mol. of CHCl3, m. 160° (decomposition), and with 1 mol. of CCl4, each of which is only slightly hygroscopic; hydrolysis with dilute NaOH gives tri(1-naphthyl)phosphine oxide hydrate, which yields the oxide, m. 341-3°, on heating. The dibromide of III is prepared by passing CHCl3-Br over the surface of III; it is reddish, only slightly hygroscopic and does not form complexes with CHCl3 or CCl4. Anthrol and PCl3, heated 5-8 hrs. at 100-10°, give 10% of tri(1-anthranyl)phosphite, greenish yellow, hygroscopic, decomposes 182-90°; 5% H2SO4 (boiling 0.5 hr.) gives anthrone; it does not add Cl or Br but a portion is hydrolyzed and oxidized; the products isolated include 10,10-dichloroanthrone, 10-bromoanthrone, anthraquinone and 1- and 3-bromoanthraquinone; H3PO3 is also formed, but no phosphates or H3PO4. Tri(9-anthranyl) phosphine could not be prepared The color of the fluorescence of these compounds in ultraviolet light is given. The results indicate that the retardation of the reaction is less dependent on the electroneg. character of the o-Br atom than on the space relations of the aromatic residue.

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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Chemistry, like all the natural sciences, Formula: C24H30O6, begins with the direct observation of nature¡ª in this case, of matter.135861-56-2, Name is (1R)-1-((4R,4aR,8aS)-2,6-Bis(3,4-dimethylphenyl)tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)ethane-1,2-diol, SMILES is O[C@@H]([C@@H]1[C@@](OC(C2=CC=C(C)C(C)=C2)OC3)([H])[C@@]3([H])OC(C4=CC=C(C)C(C)=C4)O1)CO, belongs to chiral-nitrogen-ligands compound. In a document, author is Seo, Chris S. G., introduce the new discover.

Enantioselective Hydrogenation of Activated Aryl Imines Catalyzed by an Iron(II) P-NH-P ‘ Complex

Chiral amines are key building blocks in synthetic chemistry with numerous applications in the agricultural and pharmaceutical industries. Asymmetric imine hydrogenation, particularly with iridium catalysts, is well developed. However, imine reduction still remains challenging in the context of replacing such a precious metal with a cheap, nontoxic, and environmentally friendly substitute such as iron. Here, we report that an unsymmetrical iron P-NH-P’ catalyst that was previously shown to be effective for the asymmetric hydrogenation of aryl ketones is also a very effective catalyst for the asymmetric hydrogenation of prochiral aryl imines activated with N-diphenylphosphinoyl or N-tosyl groups. The P-NH-P’ abbreviation stands for (S,S)-(PPh2CHPhCHPhNHCH2CH2PPr2)-Pr-i. Density functional theory results suggest that, surprisingly, the NH group on the catalyst activates and orients the imine to hydride attack by hydrogen bonding to the PO or SO group on the imine nitrogen, as opposed to the imine nitrogen itself. This may explain why N-Ph and N-Bu imines are not hydrogenated.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 135861-56-2. Formula: C24H30O6.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 135861-56-2, Name is (1R)-1-((4R,4aR,8aS)-2,6-Bis(3,4-dimethylphenyl)tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)ethane-1,2-diol, molecular formula is C24H30O6, belongs to chiral-nitrogen-ligands compound. In a document, author is Muniz, Kilian, introduce the new discover, HPLC of Formula: C24H30O6.

Promoting Intermolecular C-N Bond Formation under the Auspices of Iodine(III)

CONSPECTUS: The quest for the development of new protocols that provide general conditions for oxidative carbon-nitrogen bond formation has grown over recent years. Within this context, due to feasibility and benignity considerations in biochemical sciences, reactions that rely on main group oxidants as the only promoters have received particular interest. We have recently found that simple protonolysis events enable the incorporation of nitrogenated groups of the bissulfonimide family into the coordination sphere of common PiT iodine(III) complexes such as diacetoxy iodobenzene. The products of the type ArI(OAc)(NTs2) represent rare examples of iodine(III) compounds displaying reactive iodine-nitrogen single bonds. Further protonolysis furnishes the corresponding iodine(III) compounds ArI(NTs2)(2) containing two defined iodine-nitrogen single bonds for unprecedented dual transfer of both nitrogenated groups. It is of great synthetic importance that these new compounds contain iodine-nitrogen entities, which upon dissociation in solution lead to electrophilic iodine centers and nudeophilic nitrogen groups. This has enabled the development of a body of conceptually new amination reactions, which do not rely on conventional electrophilic nitrogen reagents but rather employ iodine(III) as an electrophilic activator and bissulfonimides as the source of subsequent nucleophilic amination. Additional diversification arises from the ambident nature of bissulfonimines enabling oxygenation pathways. The exciting chemistry covered in this Account comprises structural features of the reagents (including X-ray analysis), scope and limitation in synthetic amination of different hydrocarbons (including sp-, sp(2)-, and sp(3)-hybridized centers as in acetylenes, alkenes, enols, butadienes, allenes, arenes, and alkylketones), and physical-organic and theoretical analysis of the underlying reaction mechanisms. The oxidative transformations with all their rich diversifications originate from the versatile redox chemistry of the iodine(III) and iodine(I) pair, which shares several aspects of transition metal high oxidation state chemistry. For the present aryliodine(III) reagents, steric and electronic fine-tuning is possible through accurate engineering of the arene substituent. In addition to the general reactivity of the I-N bond, chiral aryliodine(III) reagents with defined stereochemical information in the aryl backbone are conceptually compatible with this approach. Thus, the development of enantioselective amination reactions with up to 99% ee was also successful. Several of the active enantioselective reagents have been isolated and structurally characterized. Following this approach for the important class of chiral vicinal diamines, an unprecedented direct diamination of alkenes could be conducted in an enantioselective catalytic manner under full intermolecular reaction control. This latter reaction is based on the precise engineering of a chiral aryliodine(III) catalyst in combination with bismesylimide as nitrogen source. It is the consequence of the precise understanding of the reaction behavior of structurally defined bisimidoiodine(III) reagents.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 135861-56-2. HPLC of Formula: C24H30O6.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Synthetic Route of 135861-56-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 135861-56-2, Name is (1R)-1-((4R,4aR,8aS)-2,6-Bis(3,4-dimethylphenyl)tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)ethane-1,2-diol, SMILES is O[C@@H]([C@@H]1[C@@](OC(C2=CC=C(C)C(C)=C2)OC3)([H])[C@@]3([H])OC(C4=CC=C(C)C(C)=C4)O1)CO, belongs to chiral-nitrogen-ligands compound. In a article, author is Ota, Yusuke, introduce new discover of the category.

Enantioselective Intramolecular Nicholas Reaction Catalyzed by Chiral Phosphoric Acid: Enantioconvergent Synthesis of Seven-Membered Cyclic Ethers from Racemic Diols

An enantioconvergent intramolecular Nicholas reaction of racemic diols was developed using BINOL- and SPINOL-derived phosphoric acids as the chiral Bronsted acid catalyst. The developed reaction features an efficient approach to the synthesis of seven-membered cyclic ethers in a highly enantioselective manner. Further derivatization of the enantioenriched cyclic ethers, initiated by the de-complexation of the dicobalt species, afforded densely functionalized cyclic ethers having an unsaturated diester moiety without loss of enantiomeric excess.

Synthetic Route of 135861-56-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 135861-56-2.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis

Electric Literature of 135861-56-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 135861-56-2, Name is (1R)-1-((4R,4aR,8aS)-2,6-Bis(3,4-dimethylphenyl)tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)ethane-1,2-diol, SMILES is O[C@@H]([C@@H]1[C@@](OC(C2=CC=C(C)C(C)=C2)OC3)([H])[C@@]3([H])OC(C4=CC=C(C)C(C)=C4)O1)CO, belongs to chiral-nitrogen-ligands compound. In a article, author is Asokan, Kathiravan, introduce new discover of the category.

Impact of CO2-solvent separators on the degradation of benzyl-2,3-dihydroxypiperidine-1-carboxylate during preparative supercritical fluid chromatographic (SFC) purification

During a preparative separation of the cis enantiomeric pair of benzyl-2,3-dihydroxypiperidine-1-carboxylate using supercritical-fluid chromatography (SFC) with methanol modifier, significant degradation of the products in the collected fractions was observed when a Waters SFC-350 (R) (Milford, MA, USA) was used, but same was not observed when a Waters SFC-80q (R) (Milford, MA, USA) was used. Through a systematic investigation, we discovered that the compound degraded over time under an acidic condition created by the formation of methyl carbonic acid from methanol and CO2. The extent of the product degradation was dependent on the time and the concentration of CO2 remained in the product fraction, which was governed by the efficiency of CO2-methanol separation during the fraction collection. Hence, we demonstrated that the different designs of CO2-solvent separator (high pressurized cyclone in Waters SFC-350 (R) and low-pressurized vortexing separator in Waters SFC-80q (R)(R)) had a significant impact on the degradation of an acid-sensitive compound. The acidity caused by CO2 in methanol was supported by diminished degradation after a nitrogen purging or after neutralizing the collected fractions with a base. Three different solutions to overcome the degradation problem of the acid sensitive compounds using SFC-350 (R) with the high pressurized separator were investigated and demonstrated. The degraded products were isolated as four enantiomers and their relative stereochemistry were established based on 2D NMR data along with the plausible mechanism of degradation. (C) 2017 Elsevier B.V. All rights reserved.

Electric Literature of 135861-56-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 135861-56-2 is helpful to your research.

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis