One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 19035-79-1, Name is Potassium hexadecyl hydrogenphosphate, formurla is C16H34KO4P. In a document, author is Perna, Filippo M., introducing its new discovery. Computed Properties of C16H34KO4P.
First Direct Evidence of an ortho-Lithiated Aryloxetane: Solid and Solution Structure, and Dynamics
Oxetanes are key synthons for asymmetric synthesis and also effective in directing ortho-lithiation. This work first reports the solution and the solid-state structure of an ortho-lithiated aryloxetane (1-Li) in the presence/absence of a bidentate ligand such as N,N,N ‘,N ‘-tetramethylethylenediamine (TMEDA). Single crystal X-ray diffraction analysis of 1-Li revealed a singular crystallographic structure in which the asymmetric unit comprises a core where the lithium atom is coordinated to the nitrogen atom of half a molecule of TMEDA and intramolecularly stabilised by the oxetane ring oxygen. This aggregation state is unprecedented in ortho-lithiated arenes. Variable temperatures multinuclear magnetic resonance (H-1, Li-7, C-13) mono- and two-dimensional NMR studies and DFT computations supported the coexistence in solution of three chelated bridged dimeric aggregates, in slow equilibration at 180 K. The major isomer is an heterochiral aggregate on the basis of H-1,Li-7-HOESY and H-1,H-1-NOESY experiments. Conclusions were supported by the preparation of enantiomerically enriched (S)-1-Li. The privileged formation of homochiral aggregates from racemic mixtures may also have implications for the development of chiral resolution processes.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis