The Absolute Best Science Experiment for (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Catalytic Asymmetric Syntheses of Secondary Alcohols Using cis-1-Amino-2-indanols as Chiral Ligands

Both enantiomers of cis-1-amino-2-indanols (1a,b) have been used as chiral ligands in the catalytic asymmetric reduction of ketones with BH3*SMe2 affording secondary alcohols with enantiomeric excesses up to 95percent.Furthermore, some N,N-dialkyl derivatives of 1a,b catalyzed the enantioselective addition of diethylzinc to aldehydes.

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Reference£º
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis