Chemistry is an experimental science, Name: (Chloromethyl)trimethylsilane, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2344-80-1, Name is (Chloromethyl)trimethylsilane, molecular formula is C4H11ClSi, belongs to chiral-nitrogen-ligands compound. In a document, author is Manaprasertsak, Auraya.
Improved Access to Chiral Tetranaphthoazepinium-Based Organocatalysts Using Aqueous Ammonia as Nitrogen Source
The class of 3,3 ‘-diaryl substituted tetranaphthobisazepinium bromides has found wide application as highly efficient C-2-symmetrical phase-transfer catalysts (PTCs, Maruoka type catalysts). Unfortunately, the synthesis requires a large number of steps and hampers the build-up of catalyst libraries which are often desired for screening experiments. Here, we present a more economic strategy using dinaphthoazepine 7 as the common key intermediate. Only at this stage various aryl substituents are introduced, and only two individual steps are required to access target structures. This protocol was applied to synthesize ten tetranaphthobisazepinium compounds 1a-1j. Their efficiency as PTCs was tested in the asymmetric substitution of tert-butyl 2-((diphenylmethylene)amino)acetate. Enantioselectivities up to 92% have been observed with new catalysts.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 2344-80-1. Name: (Chloromethyl)trimethylsilane.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis