Category: chiral-nitrogen-ligands. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Tri(naphthalen-1-yl)phosphine, is researched, Molecular C30H21P, CAS is 3411-48-1, about Palladium-Catalyzed Coupling of Optically Active Amines with Aryl Bromides. Author is Wagaw, Seble; Rennels, Roger A.; Buchwald, Stephen L..
The coupling of enantiomerically enriched amines with aryl bromides produces the corresponding N-aryl derivatives The choice of ligand in the palladium-catalyzed coupling is critical to the formation of the anilines without loss of enantiomeric purity. While LnPd [L = P(o-tolyl)3] successfully catalyzes the intramol. aryl amination of α-substituted optically pure amines, intermol. coupling reactions with this catalyst system gives racemized products. In contrast, intermol. N-arylations employing LnPd [L = (±)-BINAP] gives products in good yields with no erosion of enantiopurity. A mechanism for the observed racemization is proposed. The utility of the intramol. process is demonstrated by the synthesis of 3, an intermediate in the formal synthesis of 4, a potent ACE inhibitor.
As far as I know, this compound(3411-48-1)Category: chiral-nitrogen-ligands can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis