In an article, author is Liang, Hao, once mentioned the application of 2344-80-1, Recommanded Product: 2344-80-1, Name is (Chloromethyl)trimethylsilane, molecular formula is C4H11ClSi, molecular weight is 122.6686, MDL number is MFCD00000878, category is chiral-nitrogen-ligands. Now introduce a scientific discovery about this category.
Enantioselective Organocatalytic Desymmetrization of Cyclopentene-1,3-diones through Formal C(sp(2))-H Amidation
An enantioselective organocatalytic desymmetrization of 2,2-disubstituted cyclopentene-1,3-diones via a formal C(sp(2))-H amidation is reported. The reaction was carried out with N-methoxy amide as the nitrogen source and commercially available cinchonidine as the catalyst under mild reaction conditions, releasing methanol as the only byproduct. It provides an efficient way to synthesize enantioenriched chiral cyclopentenyl amines bearing an all-carbon quaternary stereogenic carbon center.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis