Application of 135861-56-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 135861-56-2, Name is (1R)-1-((4R,4aR,8aS)-2,6-Bis(3,4-dimethylphenyl)tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)ethane-1,2-diol, SMILES is O[C@@H]([C@@H]1[C@@](OC(C2=CC=C(C)C(C)=C2)OC3)([H])[C@@]3([H])OC(C4=CC=C(C)C(C)=C4)O1)CO, belongs to chiral-nitrogen-ligands compound. In a article, author is Rohde, Laurence N., Jr., introduce new discover of the category.
Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus
‘Nitrogen mustard’ bis(2-chloroethyl) amine derivatives (2R, 4S, 5R)- and (2S, 4S, 5R)-2-[bis(2-chloroethyl) amino]-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (2a and 2b, respectively), C14H21Cl2N2O2P, and (2R, 4R)- and (2S, 4R)-2-[bis(2-chloroethyl) amino]-4-isobutyl-1,3,2-oxazaphospholidin-2-one (3a and 3b, respectively), C10H21Cl2N2O2P, were synthesized as a mixture of diastereomers through a 1: 1 reaction of enantiomerically pure chiral amino alcohols with bis(2-chloroethyl) phosphoramidic dichloride. Flash column chromatography yielded diastereomerically pure products, as supported by P-31 NMR. The crystal structures of 2b and 3b were obtained to determine their absolute configuration at phosphorus, and P-31 NMR chemical shift trends are proposed based on the spatial relationship of the bis(2-chloroethyl) amine moiety and the chiral substituent of the amino alcohol. Oxazaphospholidinones were observed to have a more downfield P-31 NMR chemical shift when the aforementioned substituents are in a syn configuration and vice versa for when they are anti.
Application of 135861-56-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 135861-56-2.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis¡ªI. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
,Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis