So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Patil, Dipak R.; Wagh, Yogesh B.; Ingole, Pravin G.; Singh, Kripal; Dalal, Dipak S. researched the compound: 5-(4-Pyridyl)-1H-tetrazole( cas:14389-12-9 ).Application In Synthesis of 5-(4-Pyridyl)-1H-tetrazole.They published the article 《β-Cyclodextrin-mediated highly efficient [2+3] cycloaddition reactions for the synthesis of 5-substituted 1H-tetrazoles》 about this compound( cas:14389-12-9 ) in New Journal of Chemistry. Keywords: nitrile sodium azide cycloaddition cyclodextrin catalyst; tetrazole preparation environmentally benign chem. We’ll tell you more about this compound (cas:14389-12-9).
A β-cyclodextrin-promoted [2+3] cycloaddition reaction between nitriles and NaN3 in the presence of NH4Cl in DMF at 120 °C was reported, affording various 5-substituted 1H-tetrazoles in good to excellent yields in short reaction times. The presence of β-cyclodextrin renders the formation of a precipitate-like gel in the reaction media when heated. No precipitation occurs in the absence of NaN3 and NH4Cl. The precipitation responses with other salts such as LiCl and NiCl2 were weaker than with NH4Cl. In the present paper the application of supramol. aggregates was reported for the [2+3] cycloaddition reaction. β-cyclodextrin could be recovered and reused without any significant loss of activity.
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Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis