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In addition to the literature in the link below, there is a lot of literature about this compound(1,5-Dibromopentane)Related Products of 111-24-0, illustrating the importance and wide applicability of this compound(111-24-0).

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Abdpour, Shahin; Jalili-Baleh, Leili; Nadri, Hamid; Forootanfar, Hamid; Bukhari, Syed Nasir Abbas; Ramazani, Ali; Ebrahimi, Seyed Esmaeil Sadat; Foroumadi, Alireza; Khoobi, Mehdi researched the compound: 1,5-Dibromopentane( cas:111-24-0 ).Related Products of 111-24-0.They published the article 《Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against Alzheimer’s disease》 about this compound( cas:111-24-0 ) in Bioorganic Chemistry. Keywords: pyridiniumyl alkoxy phenyl chromenone preparation cytotoxicity ADMET docking neuroprotective; chromenone pyridiniumyl alkoxy preparation human AChE BuChE inhibition antitumor; Alzheimer’s disease; Anti-amyloid aggregation; Cholinesterase inhibitors; Chromone; Neuroprotective activity; Pyridinium salts. We’ll tell you more about this compound (cas:111-24-0).

A new serise of 7-hydroxy-chromone derivatives bearing pyridine moiety I [R = H, Ph, 4-ClC6H4, etc.; R1 = H, Et; n= 3, 4, 5] were synthesized and evaluated as multifunctional agents against Alzheimer’s disease (AD). Most of the compounds I were good AChE inhibitors (IC50 = 9.8-0.71μM) and showed remarkable BuChE inhibition activity (IC50 = 1.9-0.006μM) compared with donepezil as the standard drug (IC50 = 0.023 and 3.4μM). Compounds I [R = 4-ClC6H4, R1 = H, n = 4] and I [R = 4-MeOC6H4, R1 = Et, n = 3] showed the best inhibitory activity toward AChE (IC50 = 0.71μM) and BuChE (IC50 = 0.006μM), resp. The ligand-protein docking simulations and kinetic studies revealed that compound I [R = 4-ClC6H4, R1 = H, n = 4] and I [R = 4-MeOC6H4, R1 = Et, n = 3] could bind effectively to the peripheral anionic binding site (PAS) of the AChE and BuChE through mixed-type inhibition. In addition, the most potent compounds I [R = 4-ClC6H4, 4-MeC6H4, R1 = H, Et, n = 4, 3] showed acceptable neuroprotective activity on H2O2- and Aβ-induced .neurotoxicity in PC12 cells, more than standard drugs. The compounds I could block effectively self- and AChE-induced Aβ aggregation. All the results suggest that compounds I [R = 4-ClC6H4, 4-MeC6H4, R1 = H, Et, n = 4, 3] could be considered as promising multi-target-directed ligands against AD.

In addition to the literature in the link below, there is a lot of literature about this compound(1,5-Dibromopentane)Related Products of 111-24-0, illustrating the importance and wide applicability of this compound(111-24-0).

Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis