Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3411-48-1, is researched, SMILESS is C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2, Molecular C30H21PJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Synthesis and structure-activity analysis of new phosphonium salts with potent activity against african trypanosomes, Author is Taladriz, Andrea; Healy, Alan; Flores Perez, Eddysson J.; Herrero Garcia, Vanessa; Rios Martinez, Carlos; Alkhaldi, Abdulsalam A. M.; Eze, Anthonius A.; Kaiser, Marcel; de Koning, Harry P.; Chana, Antonio; Dardonville, Christophe, the main research direction is phosphonium salt diphosphonium benzyl phenethyl bridged preparation trypanosomicide agent; quaternization diphosphonium salt preparation trypanosomicide activity QSAR field analysis; benzyl phenethyl halide preparation quaternization phosphine phosphonium trypanosomicide activity.Application In Synthesis of Tri(naphthalen-1-yl)phosphine.
A series of 73 bisphosphonium salts [R1R2R3P+(CH2)n-1,4-C6H4-L-1,4-C6H4(CH2)nP+R1R2R3]X2 and 10 monophosphonium salt derivatives [Ph-L-1,4-C6H4CH2PR1R2R3]Br, [4-MeC6H4CH2P+Ph3]X (R1-R3 = alkyl, Ph, substituted Ph, 2-thienyl, 2-furyl, 1-naphthyl; L = CO, CH2, O, SO2, NAc; X = Cl, Br) were synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma brucei (T. b. rhodesiense STIB900, T. b. brucei strain 427, TbAT1-KO, and TbB48). More than half of the compounds tested showed a submicromolar EC50 against these parasites. The compounds did not display any cross-resistance to existing diamidine therapies, such as pentamidine. In most cases, the compounds displayed a good selectivity index vs. human cell lines. None of the known T. b. brucei drug transporters were required for trypanocidal activity, although some of the bisphosphonium compounds inhibited the low affinity pentamidine transporter. It was found that phosphonium drugs act slowly to clear a trypanosome population but that only a short exposure time is needed for irreversible damage to the cells. A comparative mol. field anal. model (CoMFA) was generated to gain insights into the SAR of this class of compounds, identifying key features for trypanocidal activity.
Although many compounds look similar to this compound(3411-48-1)Application In Synthesis of Tri(naphthalen-1-yl)phosphine, numerous studies have shown that this compound(SMILES:C1=CC2=C(C=C1)C(=CC=C2)P(C1=CC=CC2=C1C=CC=C2)C1=CC=CC2=C1C=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Chiral nitrogen ligands in late transition metal-catalysed asymmetric synthesis—I. Addressing the problem of ligand lability in rhodium-catalysed hydrosilations,
Nitrogen-Containing Ligands for Asymmetric Homogeneous and Heterogeneous Catalysis